VWF and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		VWF	ATXN7
Gene Name		von Willebrand factor	ataxin 7
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding	Chromatin Binding Protein Binding
	Biological Process	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs		Antihemophilic Factor
Diseases
GWAS		Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		7450	6314
HPRD ID		01906	06365
Ensembl ID		ENSG00000110799	ENSG00000163635
Uniprot IDs		P04275	O15265 Q9UPD8
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU	2KKR
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?