VWF and TNFRSF11B

Number of citations of the paper that reports this interaction (PMID 15799029)
17

Data Source:
HPRD (in vivo)

		VWF	TNFRSF11B
Gene Name		von Willebrand factor	tumor necrosis factor receptor superfamily, member 11b
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding	Receptor Activity Cytokine Activity
	Biological Process	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization	Skeletal System Development Apoptotic Process Signal Transduction Response To Nutrient Extracellular Matrix Organization Response To Magnesium Ion Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Estrogen Negative Regulation Of Bone Resorption Response To Arsenic-containing Substance
Pathways		Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Antihemophilic Factor
Diseases
GWAS		Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)	Bone mineral density ( 18455228 23437003 22504420) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Osteoporosis ( 20548944) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B	7 interactors: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		7450	4982
HPRD ID		01906	04032
Ensembl ID		ENSG00000110799	ENSG00000164761
Uniprot IDs		P04275	O00300
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU	3URF
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction	Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Positive Regulation Of Cellular Metabolic Process Platelet Activation Regulation Of Proteolysis Cell-substrate Adhesion Regulation Of Fatty Acid Transport Endodermal Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cellular Protein Metabolic Process Peptide Cross-linking Positive Regulation Of Wound Healing Exocytosis Endoderm Formation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Endopeptidase Activity Regulation Of Catalytic Activity Blood Coagulation Hemostasis Regulation Of Acute Inflammatory Response Cell Adhesion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Endoderm Development Regulation Of Immune System Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Corticotropin-releasing Hormone Secretion Secretion By Cell Regulation Of Lipid Transport Regulation Of Blood Coagulation Multicellular Organismal Development Cellular Response To Tumor Necrosis Factor Vesicle-mediated Transport Anatomical Structure Development Regulation Of Body Fluid Levels Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Catalytic Activity Wound Healing Regulation Of Cell Adhesion
Tagcloud ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c
Tagcloud (Difference) ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	arterial atherosclerosis atherosclerotic belongs causative cli concomitantly controversial cvd depending epidemiological females g1181c genotypes glycoprotein infarction males mediating occlusive opg osteoprotegerin paod polymorphisms restriction secretory synergistic synergistically t245g t950c
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