VWF and COL3A1

Number of citations of the paper that reports this interaction (PubMedID 16420575)
0

Data Source:
BioGRID (pull down)

		VWF	COL3A1
Description		von Willebrand factor	collagen type III alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Exosome Cell Periphery	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein-folding Chaperone Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction	Blood Vessel Development In Utero Embryonic Development Neuron Migration Tissue Homeostasis Chondrocyte Differentiation Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Gene Expression Peptide Cross-linking Layer Formation In Cerebral Cortex Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Lung Development Transforming Growth Factor Beta1 Production Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Multicellular Organism Growth Aorta Development Limb Joint Morphogenesis Wound Healing Skin Development Fibroblast Proliferation Elastic Fiber Assembly Animal Organ Development Digestive Tract Development System Development Negative Regulation Of Immune Response Cartilage Development Endochondral Bone Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization Supramolecular Fiber Organization Response To Angiotensin Negative Regulation Of Neuron Migration
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs		Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic factor (recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol Rurioctocog alfa pegol	Collagenase clostridium histolyticum
Diseases		Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 27863252 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 22139419 26805783 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		28 interacting genes: ADAMTS13 ALB APOA1 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FGA FGB FGG FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B LCOR MAP3K3 NUFIP2 P4HB PROS1 RAC1 SOCS4 TNFRSF11B ZNF512B	14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF
Entrez ID		7450	1281
HPRD ID		01906	00365
Ensembl ID		ENSG00000110799	ENSG00000168542
Uniprot IDs		P04275	A0AAG2UVC5 P02461
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29 7EOW 7F49 7KWO 7P4N 7PMV 7PNF 7ZWH 8D3C 8D3D	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW 7WWR 7WWS 7XAN
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Lumen Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Fibrinolysis Protein Activation Cascade Cell-matrix Adhesion Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Lumen Blood Microparticle Platelet Activation Positive Regulation Of Cell-substrate Adhesion Protein Maturation Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Space Negative Regulation Of Coagulation Extracellular Matrix Structural Constituent Positive Regulation Of Rho Protein Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinogen Complex Extracellular Region Extracellular Matrix Fibrillar Collagen Trimer Regulation Of Body Fluid Levels Blood Coagulation, Fibrin Clot Formation Zymogen Activation Protein Processing Regulation Of Biological Quality Platelet-derived Growth Factor Binding Plasminogen Activation Cell Surface Regulation Of Signal Transduction Regulation Of Signaling Protein Folding In Endoplasmic Reticulum Regulation Of Cell Communication Positive Regulation Of Heterotypic Cell-cell Adhesion External Side Of Plasma Membrane Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Collagen Type I Trimer Extracellular Matrix Organization Regulation Of Wound Healing Extracellular Structure Organization Platelet Alpha Granule	Collagen Binding Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Space Extracellular Region Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Tyrosine Kinase Collagen Receptor Activity Response To Wounding Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet Alpha Granule Extracellular Matrix Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Matrix Structural Constituent Regulation Of Body Fluid Levels Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Regulation Of Wound Healing Regulation Of Cellular Component Organization Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Endothelial Cell Proliferation Animal Organ Development Regulation Of Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Response To Wounding Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Branching Involved In Salivary Gland Morphogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phosphorylation Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Signal Transduction
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