VWF and ADAMTS13

Number of citations of the paper that reports this interaction (PMID 12775718)
34

Data Source:
HPRD (in vitro)

		VWF	ADAMTS13
Gene Name		von Willebrand factor	ADAM metallopeptidase with thrombospondin type 1 motif, 13
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum External Side Of Plasma Membrane Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Cell Surface
	Molecular Function	Glycoprotein Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Chaperone Binding	Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Liver Development Placenta Development Platelet Degranulation Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Response To Wounding Platelet Activation Extracellular Matrix Organization Cell-substrate Adhesion Protein Homooligomerization	Protein O-linked Glycosylation Proteolysis Cell-matrix Adhesion Integrin-mediated Signaling Pathway Glycoprotein Metabolic Process Response To Toxic Substance Protein Processing Platelet Activation Response To Interferon-gamma Response To Tumor Necrosis Factor Protein O-linked Fucosylation Peptide Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Response To Interleukin-4
Pathways		Platelet Adhesion to exposed collagen p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Intrinsic Pathway GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs		Antihemophilic Factor
Diseases
GWAS		Coagulation factor levels ( 23267103) Mean platelet volume ( 22139419) Platelet counts ( 22139419)	Activated partial thromboplastin time ( 22703881) Coagulation factor levels ( 23267103) Liver enzyme levels ( 18940312)
Protein-Protein Interactions		16 interactors: ADAMTS13 ATXN7 CACNA1A CALR COL1A1 COL1A2 F8 FURIN GP1BA HSPA5 ITGA2B MAP3K3 RAC1 SOCS4 TNFRSF11B ZNF512B	1 interactors: VWF
Entrez ID		7450	11093
HPRD ID		01906	04994
Ensembl ID		ENSG00000110799	ENSG00000160323
Uniprot IDs		P04275	Q76LX8
PDB IDs		1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4DMU	3GHM 3GHN 3VN4
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Response To Stress Vesicle-mediated Transport Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cell Communication Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Response To Organic Substance Signal Transduction Collagen Catabolic Process Cellular Response To Stimulus Platelet Degranulation Secretion By Cell Response To Stimulus Collagen Metabolic Process Signaling Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Positive Regulation Of Leukocyte Migration Multicellular Organismal Metabolic Process Regulation Of Cell Migration Extracellular Matrix Disassembly Regulation Of Cell Motility Secretion Regulation Of Signaling Blood Coagulation, Intrinsic Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Leukocyte Migration Regulation Of Locomotion Exocytosis Cellular Localization Regulation Of Cellular Component Movement Anatomical Structure Arrangement Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction	Blood Coagulation, Intrinsic Pathway
Tagcloud ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	addressed advances arena begun c5 complement contributed decade differentiate eculizumab encode enormous etiologies haemolytic hus measuring microangiopathies ones pneumoniae progress purpura questions shiga streptococcus thrombocytopenic thrombotic toxin unsolved uraemic
Tagcloud (Difference) ?		afflicts atrophic blanching certified counseled dealing dexterity discriminant fingers fingertips hands incorporating lifelong manipulative multifrequency nonusers numbness outside physician priority sensorineural shipyard spasms tingling vibrating vibration vibratory worker worksite	addressed advances arena begun c5 complement contributed decade differentiate eculizumab encode enormous etiologies haemolytic hus measuring microangiopathies ones pneumoniae progress purpura questions shiga streptococcus thrombocytopenic thrombotic toxin unsolved uraemic
Tagcloud (Intersection) ?