POLR1C and RSPH14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR1C	RSPH14
Description		RNA polymerase I and III subunit C	radial spoke head 14 homolog
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytoplasm Cytosol	Radial Spoke Cytoplasm Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Protein Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase I
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases		Treacher Collins syndrome
GWAS		GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Serum parathyroid hormone levels ( 27927781)
Interacting Genes		118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A DRC4 EFHC2 EP400 FH FMR1 FOXR2 GMPPB GOLGA6A GOLGA6L9 GPRASP3 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPMIP10 SPMIP2 SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TFIP11 TIAM1 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835	40 interacting genes: ABI2 AGAP1 ALS2CL AP1M1 AP2M1 BPIFA1 CCDC102B CDR2 CNTROB COG6 EPS8 FHL3 GABPB1 GOLGA2 JUP KASH5 KIFC3 KRT15 KRT31 KRT40 KRT75 KRT76 LZTS1 MNS1 PIBF1 POLR1C REL RPH3AL RSPH3 SEPTIN12 SMAD4 TCF4 TRAF2 TRIM27 TRIM50 TRIM69 TRIM7 VPS9D1 ZNF474 ZNF629
Entrez ID		9533	27156
HPRD ID		09661	16136
Ensembl ID		ENSG00000171453	ENSG00000100218
Uniprot IDs		A0A2R8YEZ4 O15160	Q9UHP6
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	8J07
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding Supramolecular Fiber Organization DNA-directed RNA Polymerase Complex Regulation Of Nucleobase-containing Compound Metabolic Process SMN Complex Actin Filament Organization RNA Polymerase I Complex Regulation Of Actin Nucleation Regulation Of Primary Metabolic Process	Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Cytoskeleton Organization Supramolecular Fiber Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Structural Molecule Activity Protein Binding Identical Protein Binding Zonula Adherens Sebaceous Gland Development Clathrin Adaptor Complex Centrosome Separation Positive Regulation Of Actin Nucleation Small GTPase Binding Innate Immune Response Epithelial Cell-cell Adhesion Clathrin Adaptor Activity
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