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POLR1C and MYD88
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
POLR1C
MYD88
Description
RNA polymerase I and III subunit C
MYD88 innate immune signal transduction adaptor
Image
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Fibrillar Center
Nucleus
Nucleoplasm
RNA Polymerase III Complex
Nucleolus
RNA Polymerase I Complex
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
Molecular Function
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Signaling Receptor Binding
Toll Binding
Death Receptor Binding
Cytokine Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Signaling Adaptor Activity
Identical Protein Binding
Molecular Adaptor Activity
TIR Domain Binding
ATP-dependent Histone Chaperone Activity
Biological Process
DNA-templated Transcription
Transcription By RNA Polymerase I
Response To Molecule Of Fungal Origin
Leukocyte Activation Involved In Inflammatory Response
Neutrophil Activation Involved In Immune Response
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Organization
Chromatin Remodeling
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Response To Virus
Induced Systemic Resistance
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Microglia Differentiation
Response To Amine
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Neurogenesis
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Response To Lipopolysaccharide
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 4 Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 8 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Defense Response To Protozoan
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Skin Development
Innate Immune Response
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Neutrophil-mediated Killing Of Bacterium
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Cytosolic sensors of pathogen-associated DNA
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
Treacher Collins syndrome
GWAS
GLP-1 levels in response to oral glucose tolerance test (fasting) (
29093273
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Interacting Genes
118 interacting genes:
ADAMTSL4
ARHGEF5
ATRIP
AVPI1
BIN3
BIRC7
BLZF1
C1orf105
C21orf58
CBX8
CBY2
CCDC33
CCNK
CCT3
CGGBP1
CLU
CORO1A
CORO1B
CRACR2A
DRC4
EFHC2
EP400
FH
FMR1
FOXR2
GMPPB
GOLGA6A
GOLGA6L9
GPRASP3
GRPEL1
GSTO2
HDX
HNRNPH1
HOXB9
HOXD12
IHO1
IKZF3
INCA1
KCTD1
KCTD13
KLF15
KRT19
KRT75
KRT76
KRTAP12-2
KRTAP3-1
LNX2
LRIF1
LZTS1
LZTS2
MBIP
MEI4
MEOX2
MKRN3
MORN3
MRPS23
MYD88
MYO5B
NDUFB10
NEDD4
NFKBIB
NIF3L1
NME1
NME4
PIH1D2
POLDIP3
POLR1D
POLR1E
POLR1G
POLR2G
POLR2J3
PPP2R3C
PSMA1
RBM48
RIMBP3
RIMBP3C
RSPH14
RUSC1
SAXO1
SMN1
SMN2
SORBS3
SPATC1L
SPMIP10
SPMIP2
SPRY1
STMN3
TASOR2
TAX1BP1
TCF4
TFIP11
TIAM1
TLE5
TMEM121
TNFAIP1
TNNI1
TRAIP
TRIM14
TRIM27
TRIOBP
TSC22D4
UNKL
USP54
VIM
WASHC1
WRN
XPA
YPEL3
ZBED1
ZBTB42
ZC2HC1C
ZFP57
ZIM2
ZNF547
ZNF554
ZNF655
ZNF688
ZNF835
44 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF152
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
Entrez ID
9533
4615
HPRD ID
09661
03703
Ensembl ID
ENSG00000171453
ENSG00000172936
Uniprot IDs
A0A2R8YEZ4
O15160
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
A0A494C0J8
Q99836
PDB IDs
7A6H
7AE1
7AE3
7AEA
7AST
7D58
7D59
7DN3
7DU2
7FJI
7FJJ
7OB9
7OBA
7OBB
7VBA
7VBB
7VBC
8A43
8ITY
8IUE
8IUH
9FSO
9FSP
9FSQ
9FSR
9FSS
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
7BEQ
7BER
7L6W
8S78
8W8M
Enriched GO Terms of Interacting Partners
?
Protein Binding
Nucleus
Identical Protein Binding
Supramolecular Fiber Organization
DNA-directed RNA Polymerase Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
SMN Complex
Actin Filament Organization
RNA Polymerase I Complex
Regulation Of Actin Nucleation
Regulation Of Primary Metabolic Process
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Defense Response
Positive Regulation Of Cytokine Production
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Defense Response To Other Organism
Positive Regulation Of Immune Response
Defense Response
Positive Regulation Of Gene Expression
Regulation Of Cytokine Production
Response To Other Organism
Defense Response To Symbiont
Response To External Biotic Stimulus
Positive Regulation Of Immune System Process
Immune System Process
Immune Response
Regulation Of Immune System Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Signal Transduction
Regulation Of Interferon-beta Production
Inflammatory Response
Positive Regulation Of Interleukin-8 Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Interferon-beta Production
Cell Surface Toll-like Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Interleukin-8 Production
Interleukin-1-mediated Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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