POLR1C and BIRC7

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		POLR1C	BIRC7
Gene Name		polymerase (RNA) I polypeptide C, 30kDa	baculoviral IAP repeat containing 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol	Nucleus Cytoplasm Golgi Apparatus Spindle Microtubule
	Molecular Function	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Dimerization Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Ligase Activity Enzyme Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic	Activation Of JUN Kinase Activity Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Regulation Of Natural Killer Cell Apoptotic Process Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Termination NoRC negatively regulates rRNA expression RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Chain Elongation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ATRIP BIRC7 CCDC33 CCDC36 CD3EAP CLU CORO1A CORO1B FAM154A FAM208B IKZF3 KCTD1 KRT19 LZTS2 MBIP MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E POLR2J PPP2R3C RIMBP3 SMN2 TCF4 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN	18 interactors: AES BIRC2 CASP3 CASP7 CASP9 DDX6 DIABLO FAM124B HTRA2 PHF1 POLR1C UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2I UBE2K
Entrez ID		9533	79444
HPRD ID		09661	05761
Ensembl ID		ENSG00000171453	ENSG00000101197
Uniprot IDs		O15160	Q96CA5
PDB IDs			1OXN 1OXQ 1OY7 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GT9 3GTA 3UW5 4AUQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production Cytoskeleton Organization DNA-templated Transcription, Elongation Cellular Component Assembly Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Response To Stress Actin Filament-based Process Transcription From RNA Polymerase I Promoter Regulation Of Type I Interferon Production Organelle Organization Innate Immune Response Regulation Of Cytokine Production Nucleobase-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Actin Cytoskeleton Organization Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cytokine Production Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Immune Response Immune System Process DNA-templated Transcription, Termination Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transcription, DNA-templated Negative Regulation Of Actin Nucleation Response To Stimulus Regulation Of Apoptotic Process RNA Biosynthetic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Death Glial Cell Development Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Cellular Process Actin Filament Organization Regulation Of Actin Nucleation RNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process	Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Protein Polyubiquitination Proteolysis Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Protein Ubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Modification By Small Protein Conjugation Catabolic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Protein Processing Regulation Of Cellular Protein Metabolic Process Cell Death Death Toll-like Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Peptidase Activity Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Metabolic Process
Tagcloud ?		add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing	actg1 alteration chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		add biosynthesis burgeoning codified codifies collins constituent crest disrupts elucidating genetics hemizygous heterozygosity illustrating implicates nascent neuroepithelium pathophysiology planning playing researchers ribosome tcof1 tcs treacher treacle underpinnings utilizing	actg1 alteration chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?