POLR1C and HOXD12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR1C	HOXD12
Description		RNA polymerase I and III subunit C	homeobox D12
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytoplasm Cytosol	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase I	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Digit Morphogenesis
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases		Treacher Collins syndrome
GWAS		GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Male-pattern baldness ( 28196072)
Interacting Genes		118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A DRC4 EFHC2 EP400 FH FMR1 FOXR2 GMPPB GOLGA6A GOLGA6L9 GPRASP3 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPMIP10 SPMIP2 SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TFIP11 TIAM1 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835	17 interacting genes: ACTN3 CABP2 CREBBP DTX2 FGF14 FRS3 MAF MAFB MAFF MAFG MAFK MEIS1 MKRN3 POLR1C TFAP2D TRAF1 TTC19
Entrez ID		9533	3238
HPRD ID		09661	00871
Ensembl ID		ENSG00000171453	ENSG00000170178
Uniprot IDs		A0A2R8YEZ4 O15160	P35452
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding Supramolecular Fiber Organization DNA-directed RNA Polymerase Complex Regulation Of Nucleobase-containing Compound Metabolic Process SMN Complex Actin Filament Organization RNA Polymerase I Complex Regulation Of Actin Nucleation Regulation Of Primary Metabolic Process	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of Transcription By RNA Polymerase II Fibroblast Growth Factor Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Identical Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Rhombomere 6 Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epidermis Development Regulation Of Epidermal Cell Differentiation Abducens Nerve Formation Rhombomere 5 Development Inferior Colliculus Development Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Regulation Of Cell Differentiation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Brain Segmentation
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