POLR1C and DRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR1C	DRC4
Description		RNA polymerase I and III subunit C	dynein regulatory complex subunit 4
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytoplasm Cytosol	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Protein Binding Microtubule Binding Small GTPase Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase I	Microtubule Cytoskeleton Organization Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Brain Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Motility Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Positive Regulation Of Protein Localization To Cilium
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Activation of SMO
Drugs
Diseases		Treacher Collins syndrome
GWAS		GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A DRC4 EFHC2 EP400 FH FMR1 FOXR2 GMPPB GOLGA6A GOLGA6L9 GPRASP3 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPMIP10 SPMIP2 SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TFIP11 TIAM1 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835	110 interacting genes: ARL6IP1 BCAR3 BORCS6 BYSL C1orf35 CARD10 CARD9 CBFA2T3 CCDC125 CCDC146 CCDC6 CCHCR1 CCNG1 CDC37 CDR2 CEP70 CFAP53 CINP CKS1B COG6 CPSF7 CRYBB1 CT45A1 CWF19L2 CYSRT1 DAXX DDX17 DISC1 DMAP1 EAF1 EHHADH EIF1AD ERCC1 EVI5L FAM161A FAM161B FHL2 GADD45GIP1 GCC1 GEM GOLGA2 GPRASP3 GRIPAP1 GSTA4 HEXIM2 HOMER3 HOMEZ HOXA1 HSF2BP IGFBP6 KDM1A KRT14 KRT15 KRT16 L3MBTL2 L3MBTL3 LASP1 LHX3 LMO1 LMO2 LZTS1 MAD1L1 MFAP1 MID2 MRFAP1L1 NDOR1 NKAPD1 PLK4 PNKP PNMA5 POLR1C POTEB3 PPFIA1 PRDM14 PRMT5 PRPF18 RALBP1 RBAK RINT1 RUBCN SCNM1 SKIL SORBS3 SP7 SPATA18 SPG21 STAC3 TCEA2 THAP1 TNFAIP3 TRAF2 TRAF5 TRIM41 TRIM54 TSFM TSGA10IP TXLNA TXLNB USHBP1 YES1 YJU2 ZBTB22 ZBTB26 ZBTB39 ZNF212 ZNF250 ZNF572 ZNF620 ZNF629 ZNF792
Entrez ID		9533	2622
HPRD ID		09661	05533
Ensembl ID		ENSG00000171453	ENSG00000141013
Uniprot IDs		A0A2R8YEZ4 O15160	A0A087WZT7 A0A384MR00 B7Z1U9 O95995
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	8J07
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding Supramolecular Fiber Organization DNA-directed RNA Polymerase Complex Regulation Of Nucleobase-containing Compound Metabolic Process SMN Complex Actin Filament Organization RNA Polymerase I Complex Regulation Of Actin Nucleation Regulation Of Primary Metabolic Process	Identical Protein Binding Protein Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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