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VCL and TLN1
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical)
HPRD
(in vitro)
VCL
TLN1
Description
vinculin
talin 1
Image
GO Annotations
Cellular Component
Podosome
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Brush Border
Cell-cell Junction
Adherens Junction
Zonula Adherens
Fascia Adherens
Focal Adhesion
Actin Cytoskeleton
Membrane
Myofibril
Cell-substrate Junction
Protein-containing Complex
Secretory Granule Lumen
Specific Granule Lumen
Sarcolemma
Cell Projection
Costamere
Cell-cell Contact Zone
Membrane Raft
Perinuclear Region Of Cytoplasm
Podosome Ring
Extracellular Exosome
Anchoring Junction
Outer Dense Plaque Of Desmosome
Inner Dense Plaque Of Desmosome
Extracellular Vesicle
Ficolin-1-rich Granule Lumen
Terminal Web
Ruffle
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Membrane
Ruffle Membrane
Cell Projection
Extracellular Exosome
Anchoring Junction
Molecular Function
Dystroglycan Binding
Actin Binding
Structural Molecule Activity
Protein Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Alpha-catenin Binding
Cadherin Binding
Molecular Adaptor Activity
Phosphatidylserine Binding
Actin Binding
Integrin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Vinculin Binding
LIM Domain Binding
Phosphatidylinositol Binding
Cadherin Binding
Actin Filament Binding
Biological Process
Morphogenesis Of An Epithelium
Cell Adhesion
Cell-matrix Adhesion
Lamellipodium Assembly
Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Adherens Junction Assembly
Protein Localization To Cell Surface
Maintenance Of Blood-brain Barrier
Apical Junction Assembly
Axon Extension
Regulation Of Focal Adhesion Assembly
Platelet Aggregation
Epithelial Cell-cell Adhesion
Regulation Of Establishment Of Endothelial Barrier
Regulation Of Protein Localization To Adherens Junction
Cell-cell Junction Assembly
Cell-substrate Junction Assembly
Cell Adhesion
Integrin-mediated Signaling Pathway
Actin Cytoskeleton Organization
Cortical Actin Cytoskeleton Organization
Integrin Activation
Cortical Microtubule Organization
Regulation Of Focal Adhesion Assembly
Platelet Aggregation
Cell-cell Adhesion
Pathways
Platelet degranulation
Smooth Muscle Contraction
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ALK fusions and activated point mutants
Regulation of CDH1 Function
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Platelet degranulation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
XBP1(S) activates chaperone genes
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS
Cardiac troponin-I levels (
31014085
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Left ventricular internal dimension in diastole (
29403010
)
Primary tooth development (number of teeth) (
23704328
)
Primary tooth development (time to first tooth eruption) (
23704328
)
Refractive error (
32231278
)
Brain morphology (MOSTest) (
32665545
)
IgE levels in asthmatics (
23967269
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
38 interacting genes:
ABI2
ACTA1
ACTN1
BCAR1
BIRC6
BRME1
CDH1
CLTC
CORO2B
CTNNA1
ENOX2
GSN
ITGA5
LINC01554
LPXN
NEBL
NRAP
PKD1
POMP
PRKCA
PRPF40A
PSME1
PTK2
PXN
RAVER1
SAPCD2
SELE
SORBS1
SORBS2
SORBS3
SRC
TEKT1
TGFB1I1
TLN1
TRIM15
TRIP6
TUBA1A
VASP
37 interacting genes:
ABI1
ACTA1
ARHGAP31
AZIN2
CDK5
CEBPA
DAG1
DOK1
EGFR
ERBB2
FMO1
HSP90AA1
ITGA1
ITGA2B
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
LRP2
MTNR1A
MTNR1B
NRAP
NYAP1
PIP5K1C
PKD1
PTK2
PTK2B
PXN
RET
SMURF1
SUMO2
TES
TPTE
TUBA1A
VCL
YWHAQ
Entrez ID
7414
7094
HPRD ID
01900
01726
Ensembl ID
ENSG00000035403
ENSG00000137076
Uniprot IDs
B3KXA2
P18206
V9HWK2
Q9Y490
PDB IDs
1RKC
1RKE
1SYQ
1TR2
1YDI
2GWW
2HSQ
2IBF
3H2U
3H2V
3JBK
3MYI
3RF3
3S90
3TJ5
3TJ6
3VF0
4DJ9
4EHP
4LN2
4LNP
4PR9
5L0C
5L0D
5L0F
5L0G
5L0H
5L0I
5L0J
5O2Q
6FUY
6UPW
7KTT
7KTU
7KTV
7KTW
1SYQ
2MWN
4DJ9
6R9T
Enriched GO Terms of Interacting Partners
?
Anchoring Junction
Focal Adhesion
Vinculin Binding
Cell-substrate Junction Assembly
Cell-substrate Junction Organization
Cell Junction Assembly
Cell Adhesion
Cytoskeleton
Actin Filament Organization
Cell Junction Organization
Lamellipodium
Supramolecular Fiber Organization
Stress Fiber
Cellular Component Assembly
Focal Adhesion Assembly
Actin Cytoskeleton
Cytoplasm
Cell-substrate Adhesion
Integrin-mediated Signaling Pathway
Cytoskeleton Organization
Actin Binding
Cell Motility
Actin Filament Binding
Cell Migration
Signal Complex Assembly
Integrin Binding
Flotillin Complex
Regulation Of Cytoskeleton Organization
Actin Filament-based Process
Structural Constituent Of Cytoskeleton
Regulation Of Cell Adhesion
Cell-cell Junction Assembly
Negative Regulation Of Anoikis
Actin Cytoskeleton Organization
Cardiac Muscle Thin Filament Assembly
Cytoskeletal Protein Binding
Regulation Of Actin Filament Organization
Regulation Of Anoikis
Regulation Of Cellular Component Organization
Positive Regulation Of Supramolecular Fiber Organization
Actin Filament
Plasma Membrane
Cell-cell Junction Organization
Cellular Response To Indole-3-methanol
Cytosol
Positive Regulation Of Cytoskeleton Organization
Cell Projection
Adherens Junction
Protein-containing Complex Assembly
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion
Cell-matrix Adhesion
Cell-substrate Adhesion
Integrin Complex
Integrin-mediated Signaling Pathway
Cell Migration
Receptor Complex
Cell Motility
Cell Adhesion
Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Adhesion Mediated By Integrin
Lamellipodium
Enzyme-linked Receptor Protein Signaling Pathway
Filopodium
Virus Receptor Activity
Regulation Of Protein Metabolic Process
Cell Surface
Anchoring Junction
Cell Projection
Symbiont Entry Into Host Cell
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Extracellular Exosome
Signal Complex Assembly
Developmental Process
Integrin Binding
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Protein Metabolic Process
Heterotypic Cell-cell Adhesion
Biological Process Involved In Interaction With Host
Neuron Projection Morphogenesis
Protein Phosphatase Binding
Vinculin Binding
Cell Projection Morphogenesis
Cell Projection Organization
Ruffle Membrane
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Wound Healing, Spreading Of Epidermal Cells
Integrin Alpha1-beta1 Complex
Regulation Of Cell Migration
Positive Regulation Of Fibroblast Migration
Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Cell-matrix Adhesion
Regulation Of Cell Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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