VCL and SORBS1

Number of citations of the paper that reports this interaction (PMID 10085297)
38

Data Source:
HPRD (in vivo, in vitro)

		VCL	SORBS1
Gene Name		vinculin	sorbin and SH3 domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Cell-substrate Junction Vesicle Costamere Protein Complex Extracellular Vesicular Exosome	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Morphogenesis Of An Epithelium Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Cell Adhesion Cell-matrix Adhesion Blood Coagulation Lamellipodium Assembly Platelet Activation Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Apical Junction Assembly Axon Extension Platelet Aggregation Epithelial Cell-cell Adhesion	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Response to elevated platelet cytosolic Ca2+ Smooth Muscle Contraction Platelet degranulation Platelet activation, signaling and aggregation	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		27 interactors: ABI2 ACTA1 ACTN1 C19orf57 CDH1 CLTC CORO2B CTNNA1 GSN NRAP PKD1 PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SELE SORBS1 SORBS2 SRC TEKT1 TGFB1I1 TLN1 TRIP6 TUBA1A VASP	25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		7414	10580
HPRD ID		01900	05587
Ensembl ID		ENSG00000035403	ENSG00000095637
Uniprot IDs		B3KXA2 P18206	Q9BX66
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP	2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Junction Assembly Cell-cell Junction Organization Actin Filament-based Process Organelle Organization Adherens Junction Organization Actin Filament Organization Actin Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Junction Assembly Regulation Of Cellular Component Organization Regulation Of Cellular Component Movement Focal Adhesion Assembly Signal Complex Assembly Cell-cell Junction Assembly Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Adherens Junction Assembly Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Locomotion Response To Organic Substance Response To Wounding Cell-matrix Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Projection Organization Cell Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Body Fluid Levels Platelet Activation Regulation Of Cell Migration Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Locomotion Blood Coagulation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Hemostasis Cellular Response To Stimulus Protein Complex Assembly Cell Development Cellular Response To Organonitrogen Compound Integrin-mediated Signaling Pathway Cellular Response To Organic Substance	Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Tagcloud ?		34a 34c analyse chimeras crick destabilizing differs fkbp8 implement micrornas mir mirna nucleotides observe overlap overlapping pairing perfect preferential psilac raising repress repressed resource seed subsets untranslated want watson	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		34a 34c analyse chimeras crick destabilizing differs fkbp8 implement micrornas mir mirna nucleotides observe overlap overlapping pairing perfect preferential psilac raising repress repressed resource seed subsets untranslated want watson	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?