VCL and SRC

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		VCL	SRC
Description		vinculin	SRC proto-oncogene, non-receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Myofibril Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Cell Projection Costamere Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Podosome Ring Extracellular Exosome Anchoring Junction Outer Dense Plaque Of Desmosome Inner Dense Plaque Of Desmosome Extracellular Vesicle Ficolin-1-rich Granule Lumen Terminal Web	Podosome Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Late Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Membrane Cell Junction Ruffle Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Protein Domain Specific Binding Heme Binding Protein Tyrosine Kinase Activator Activity Signaling Receptor Activator Activity Ionotropic Glutamate Receptor Binding SH2 Domain Binding Phospholipase Binding Transmembrane Transporter Binding Cadherin Binding Ephrin Receptor Binding ATPase Binding Phosphoprotein Binding BMP Receptor Binding Connexin Binding Scaffold Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Processing Macroautophagy Cell Migration Protein Deubiquitination Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of Telomere Maintenance Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Integrin Activation Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Positive Regulation Of Dephosphorylation Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Osteoclast Development Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Angiotensin-activated Signaling Pathway TORC1 Signaling Vasodilation Odontogenesis Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Bone Resorption Bone Resorption Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Glycolytic Process Symbiont Entry Into Host Cell Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Oogenesis Progesterone Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitochondrial Depolarization Uterus Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cell Projection Assembly Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Peptide Hormone Stimulus Cellular Response To Progesterone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neutrophil Activation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Caveolin-mediated Endocytosis
Pathways		Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ALK fusions and activated point mutants Regulation of CDH1 Function High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling RHOU GTPase cycle Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation GPER1 signaling Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by CSF1 (M-CSF) in myeloid cells Degradation of CDH1
Drugs			Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric acid Paratoulene phosphate 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Tirbanibulin Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL PD-168393 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile PP-121 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib Fostamatinib
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Retinopathy in non-diabetics ( 23393555) Rheumatoid arthritis ( 30891314) Squamous cell carcinoma ( 26908436)
Interacting Genes		38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP	303 interacting genes: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 AFAP1 AFAP1L2 AGAP1 AHR AKT1 ALDOB ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARR3 ASAP1 ATG9A ATP2B4 AXL BAAT BCAR1 BCCIP BCR BMX BRMS1 CA3 CASP8 CAV1 CAV2 CBL CBLC CCDC180 CCNA1 CD2AP CD33 CD36 CD44 CD46 CD47 CD59 CDC25A CDCP1 CDH5 CDK1 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 COASY CORO7 CRMP1 CSK CTNNB1 CTNND1 CTSV CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 DUSP12 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 EMD ENO1 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESR1 ESR2 ETS1 ETS2 EVL FANCC FARP2 FASLG FBP2 FBXO5 FGR FHIT FLNA FLT3 FOXO1 FRS2 FYB1 FZR1 GAB1 GAB2 GAB3 GALNT12 GFAP GIT1 GJA1 GJB1 GRB10 GRB2 GRIN2A GRIN2B GRK2 GTF2I GUCY2C HDAC3 HEMGN HLA-A HLA-B HNF1A HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LATS2 LRP1 MAP2 MAP2K1 MAPK15 MAPK3 MAPK8IP3 MAPRE1 MAPT MATK MDM2 MED28 MET MICAL1 MPZL1 MST1R MT-ND2 MUC1 MYLK NANS NCOA6 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1I2 NR1I3 NR3C1 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PIK3R3 PIP5K1C PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARD PPARGC1B PPP2CB PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PROM1 PTK2 PTK2B PTPA PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRC PTPRE PXN RACK1 RAF1 RARA RASA1 RASGRF1 RET RGS16 RPL10 RPS6KA3 RPS6KB1 RPS6KB2 RXRA SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCE1 SNCA SOCS1 SORBS1 SPTAN1 SRCIN1 SRF SRPK2 STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 STX17 SYK SYN1 TAMALIN TERT THRA THRB TIAM1 TMPO TNFRSF11A TNFRSF1A TNK2 TP53 TRAF1 TRAF3 TRAF6 TRAT1 TRIM50 TRIM7 TRIP10 TRIP6 TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX XPA YTHDC1 YWHAB YWHAE YWHAG YWHAH ZNF189
Entrez ID		7414	6714
HPRD ID		01900	01819
Ensembl ID		ENSG00000035403	ENSG00000197122
Uniprot IDs		B3KXA2 P18206 V9HWK2	P12931
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW 7KTT 7KTU 7KTV 7KTW	1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ 6ATE 6C4S 6E6E 6EHJ 7NG7 7OTE 7T1U 7YQE 8GWH 8HAQ 8JF3 8JN8 8JN9 8VCF 8VCG
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Vinculin Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Cell Junction Assembly Cell Adhesion Cytoskeleton Actin Filament Organization Cell Junction Organization Lamellipodium Supramolecular Fiber Organization Stress Fiber Cellular Component Assembly Focal Adhesion Assembly Actin Cytoskeleton Cytoplasm Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cytoskeleton Organization Actin Binding Cell Motility Actin Filament Binding Cell Migration Signal Complex Assembly Integrin Binding Flotillin Complex Regulation Of Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Cytoskeleton Regulation Of Cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Anoikis Actin Cytoskeleton Organization Cardiac Muscle Thin Filament Assembly Cytoskeletal Protein Binding Regulation Of Actin Filament Organization Regulation Of Anoikis Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Actin Filament Plasma Membrane Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cytosol Positive Regulation Of Cytoskeleton Organization Cell Projection Adherens Junction Protein-containing Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Plasma Membrane Regulation Of Cell Communication Regulation Of Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cytosol Cytoplasm Regulation Of Developmental Process Positive Regulation Of Cell Communication Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette Developmental Process Positive Regulation Of Macromolecule Metabolic Process Focal Adhesion Protein Kinase Activity Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Motility Regulation Of Cell Migration Negative Regulation Of Signal Transduction Regulation Of Cell Differentiation Regulation Of Biological Quality Positive Regulation Of Immune System Process Phosphorylation
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