VCL and CORO2B

Number of citations of the paper that reports this interaction (PubMedID 10224093)
0

Data Source:
HPRD (in vivo, in vitro)

		VCL	CORO2B
Description		vinculin	coronin 2B
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Myofibril Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Cell Projection Costamere Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Podosome Ring Extracellular Exosome Anchoring Junction Outer Dense Plaque Of Desmosome Inner Dense Plaque Of Desmosome Extracellular Vesicle Ficolin-1-rich Granule Lumen Terminal Web	Cytoplasm Cytoskeleton Focal Adhesion Actin Cytoskeleton Membrane
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity	Actin Binding Protein Binding Vinculin Binding Actin Filament Binding Talin Binding
	Biological Process	Morphogenesis Of An Epithelium Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction	Regulation Of Glomerular Filtration Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Focal Adhesion Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Stress Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization
Pathways		Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ALK fusions and activated point mutants Regulation of CDH1 Function High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	Cognitive performance ( 19734545) PR interval ( 32439900) Systolic blood pressure ( 26969751)
Interacting Genes		38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP	5 interacting genes: ACTA1 APPBP2 RSPH1 TSC22D1 VCL
Entrez ID		7414	10391
HPRD ID		01900	05416
Ensembl ID		ENSG00000035403	ENSG00000103647
Uniprot IDs		B3KXA2 P18206 V9HWK2	Q9UQ03
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW 7KTT 7KTU 7KTV 7KTW
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Vinculin Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Cell Junction Assembly Cell Adhesion Cytoskeleton Actin Filament Organization Cell Junction Organization Lamellipodium Supramolecular Fiber Organization Stress Fiber Cellular Component Assembly Focal Adhesion Assembly Actin Cytoskeleton Cytoplasm Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cytoskeleton Organization Actin Binding Cell Motility Actin Filament Binding Cell Migration Signal Complex Assembly Integrin Binding Flotillin Complex Regulation Of Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Cytoskeleton Regulation Of Cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Anoikis Actin Cytoskeleton Organization Cardiac Muscle Thin Filament Assembly Cytoskeletal Protein Binding Regulation Of Actin Filament Organization Regulation Of Anoikis Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Actin Filament Plasma Membrane Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cytosol Positive Regulation Of Cytoskeleton Organization Cell Projection Adherens Junction Protein-containing Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway	Sensory Perception Of Itch Sneeze Reflex Positive Regulation Of Testosterone Secretion Neuromedin B Receptor Binding Positive Regulation Of Osteoclast Proliferation Leydig Cell Proliferation Regulation Of Protein Localization To Adherens Junction Inner Dense Plaque Of Desmosome Podosome Ring Terminal Web Outer Dense Plaque Of Desmosome Radial Spoke Head 1 Radial Spoke Head 3 Cytoskeleton Positive Regulation Of Respiratory Gaseous Exchange Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Regulation Of Protein Localization To Cell-cell Junction Molecular Adaptor Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Radial Spoke Head Cell-substrate Junction Outer Dense Fiber Apical Junction Assembly Zonula Adherens Fascia Adherens
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