VCL and TGFB1I1

Number of citations of the paper that reports this interaction (PMID 9858471)
41

Data Source:
BioGRID (pull down)

		VCL	TGFB1I1
Gene Name		vinculin	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Cell-substrate Junction Vesicle Costamere Protein Complex Extracellular Vesicular Exosome	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Morphogenesis Of An Epithelium Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Cell Adhesion Cell-matrix Adhesion Blood Coagulation Lamellipodium Assembly Platelet Activation Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Apical Junction Assembly Axon Extension Platelet Aggregation Epithelial Cell-cell Adhesion	Transcription From RNA Polymerase II Promoter Cell Adhesion Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Response to elevated platelet cytosolic Ca2+ Smooth Muscle Contraction Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		27 interactors: ABI2 ACTA1 ACTN1 C19orf57 CDH1 CLTC CORO2B CTNNA1 GSN NRAP PKD1 PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SELE SORBS1 SORBS2 SRC TEKT1 TGFB1I1 TLN1 TRIP6 TUBA1A VASP	29 interactors: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		7414	7041
HPRD ID		01900	03831
Ensembl ID		ENSG00000035403	ENSG00000140682
Uniprot IDs		B3KXA2 P18206	O43294
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cell Junction Assembly Cell-cell Junction Organization Actin Filament-based Process Organelle Organization Adherens Junction Organization Actin Filament Organization Actin Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Junction Assembly Regulation Of Cellular Component Organization Regulation Of Cellular Component Movement Focal Adhesion Assembly Signal Complex Assembly Cell-cell Junction Assembly Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Adherens Junction Assembly Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Locomotion Response To Organic Substance Response To Wounding Cell-matrix Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Projection Organization Cell Differentiation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Body Fluid Levels Platelet Activation Regulation Of Cell Migration Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Locomotion Blood Coagulation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Hemostasis Cellular Response To Stimulus Protein Complex Assembly Cell Development Cellular Response To Organonitrogen Compound Integrin-mediated Signaling Pathway Cellular Response To Organic Substance	Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Cell Activation Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Signal Transduction Response To Stimulus Regulation Of Catalytic Activity Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Organ Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Cell Surface Receptor Signaling Pathway System Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Anatomical Structure Development Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Negative Regulation Of Signaling Cellular Response To Stimulus Multicellular Organismal Development Regulation Of Cellular Process Positive Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		34a 34c analyse chimeras crick destabilizing differs fkbp8 implement micrornas mir mirna nucleotides observe overlap overlapping pairing perfect preferential psilac raising repress repressed resource seed subsets untranslated want watson	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Difference) ?		34a 34c analyse chimeras crick destabilizing differs fkbp8 implement micrornas mir mirna nucleotides observe overlap overlapping pairing perfect preferential psilac raising repress repressed resource seed subsets untranslated want watson	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Intersection) ?