TUBA4A and RAB8B

Number of citations of the paper that reports this interaction (PMID 12639940)
17

Data Source:
HPRD (in vivo)

		TUBA4A	RAB8B
Gene Name		tubulin, alpha 4a	RAB8B, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome	Mitochondrion Endosome Peroxisomal Membrane Plasma Membrane Synaptic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Phagocytic Vesicle Membrane Phagocytic Vesicle Perinuclear Region Of Cytoplasm Cell Tip Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	GTPase Activity Receptor Binding Protein Binding GTP Binding GDP Binding TPR Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization	Vesicle Docking Involved In Exocytosis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Cell Projection Organization Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Adherens Junction Organization Cilium Assembly Protein Import Into Peroxisome Membrane Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Corticotropin Secretion Protein Localization To Plasma Membrane
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs		Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS
Protein-Protein Interactions		49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70	7 interactors: APP CDH1 RAB3IP RALA TUBA4A TUBB VIM
Entrez ID		7277	51762
HPRD ID		01851	11476
Ensembl ID		ENSG00000127824	ENSG00000166128
Uniprot IDs		A8MUB1 P68366	F5GY21 Q92930
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process	Cellular Localization Organelle Organization Lens Fiber Cell Differentiation Cellular Component Assembly Establishment Of Localization In Cell Exocytosis Cell Cycle Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Platelet Degranulation Cell Division Execution Phase Of Apoptosis Synapse Assembly Cell Cycle Secretion By Cell Lens Development In Camera-type Eye Protein Polymerization Vesicle-mediated Transport Regulation Of Body Fluid Levels G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Secretion Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Regulation Of Neurogenesis Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Microtubule-based Process Synapse Organization Membrane Raft Localization Negative Regulation Of Neuron Differentiation Platelet Activation Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Indole-3-methanol Regulation Of Cell Development Membrane Organization Epithelial Cell Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Activation Of Anaphase-promoting Complex Activity Axon Choice Point Recognition Establishment Of Protein Localization To Membrane Apoptotic Process Central Nervous System Development Bergmann Glial Cell Differentiation Salivary Gland Cavitation Programmed Cell Death Mitotic Cell Cycle Phase Transition Protein Complex Assembly Cell Cycle Phase Transition
Tagcloud ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	1a 1b adaptor addiction ap2 ca1 cation channels cyclic electrophysiology gated hcn hcn1 hcn2 hippocampal hyperpolarization imbalance learning ltp maze morphine mu2 neurological pka potentiation sc tpr trip8b vital
Tagcloud (Difference) ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	1a 1b adaptor addiction ap2 ca1 cation channels cyclic electrophysiology gated hcn hcn1 hcn2 hippocampal hyperpolarization imbalance learning ltp maze morphine mu2 neurological pka potentiation sc tpr trip8b vital
Tagcloud (Intersection) ?