TUBA4A and HSPH1

Number of citations of the paper that reports this interaction (PubMedID 12749852)
0

Data Source:
HPRD (two hybrid)

		TUBA4A	HSPH1
Description		tubulin alpha 4a	heat shock protein family H (Hsp110) member 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Protein Folding Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of NK T Cell Activation
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	Phenethyl Isothiocyanate
Diseases
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Metabolite levels ( 23823483)
Interacting Genes		53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70	20 interacting genes: ADD1 CEBPA CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 FNDC3B HSPA13 HSPA8 NEDD8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2
Entrez ID		7277	10808
HPRD ID		01851	09990
Ensembl ID		ENSG00000127824	ENSG00000120694
Uniprot IDs		P68366	A0A0A0MSM0 B4DY72 Q92598
PDB IDs			6GFA
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Regulation Of Proteolysis Regulation Of Cell Size Protein Kinase CK2 Complex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cytoplasm Regulation Of Cellular Component Size Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Nucleotide Binding ATP Binding Protein Targeting To Vacuole Involved In Autophagy Microtubule Cytoskeleton Organization Positive Regulation Of Embryonic Development Cellular Response To Stress Microtubule-based Process PML Body PcG Protein Complex Protein Refolding Negative Regulation Of Cellular Component Organization Negative Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Cellular Response To Metal Ion Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Growth Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Protein Depolymerization Positive Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Cell Leading Edge Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Translocation Complex Disassembly ATP-dependent Protein Folding Chaperone Dynein Intermediate Chain Binding Central Nervous System Neuron Axonogenesis Phosphoglycerate Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Stress Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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