TUBA4A and VDAC1

Number of citations of the paper that reports this interaction (PubMedID 12087096)
0

Data Source:
HPRD (in vivo)

		TUBA4A	VDAC1
Description		tubulin alpha 4a	voltage dependent anion channel 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Synapse Pore Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Transmembrane Transporter Binding Ceramide Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Behavioral Fear Response Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Apoptotic Process Chemical Synaptic Transmission Neuron-neuron Synaptic Transmission Learning Epithelial Cell Differentiation Calcium Import Into The Mitochondrion Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Monoatomic Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Type 2 Mitophagy Mitochondrial Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70	26 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SAMM50 STUB1 SUMO4 TOMM20 TUBA4A
Entrez ID		7277	7416
HPRD ID		01851	05137
Ensembl ID		ENSG00000127824	ENSG00000213585
Uniprot IDs		P68366	A0A1L1UHR1 B3KTS5 P21796
PDB IDs			2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR 7QI2 8J0O
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Mitochondrial Outer Membrane Bcl-2 Family Protein Complex Apoptotic Mitochondrial Changes Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Membrane Organization Mitochondrion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Permeability BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Regulation Of Apoptotic Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Membrane Permeability Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Channel Activity Programmed Cell Death Thymocyte Apoptotic Process Cell Death Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response BAK Complex B Cell Negative Selection Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Regulation Of Protein-containing Complex Assembly Cellular Response To Unfolded Protein Mitochondrial Fusion Positive Regulation Of Intracellular Signal Transduction Membrane Organization Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Establishment Of Protein Localization To Mitochondrion
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