TUBA4A and CDK5R2

Data Source: HiPPIP (Novel)

		TUBA4A	CDK5R2
Name		tubulin alpha 4a	cyclin dependent kinase 5 regulatory subunit 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Cytoplasm Plasma Membrane Membrane Protein Kinase 5 Complex Growth Cone Neuron Projection Presynapse
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Actin Binding Lipid Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Axon Guidance Brain Development Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cytoskeleton Organization
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	NGF-stimulated transcription
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	None
GWAS		Platelet distribution width ( 27863252 32888494 ) Severe autoimmune type 2 diabetes ( 34737425 )	Male-pattern baldness ( 28196072 ) Obesity-related traits ( 23251661 ) QT interval ( 29213071 ) Refractive error ( 32231278 )
Novel Interactors		14 novel interactors: ALPP ATP5MC3 CAPN2 CDK5R2 CXCR1 DPYSL2 ETV6 HPCA IL1RL1 NUPR1 SKP1 SLC11A1 STK16 WNT6	1 novel interactors: TUBA4A
Interacting Genes		53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70	4 interacting genes: ACTB ACTN1 CAMK2A CDK5
Entrez ID		7277	8941
HPRD ID		01851	04790
Ensembl ID		ENSG00000127824	ENSG00000171450
Uniprot IDs		P68366	Q13319
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Cell Junction Assembly Synapse Regulation Of Synaptic Vesicle Recycling Cytoskeleton Organization Organelle Organization Platelet Aggregation Tau Protein Binding Actin Cytoskeleton Organization Brush Border Actin Filament-based Process Homotypic Cell-cell Adhesion Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cellular Localization Protein Localization To Cell Junction Actin Filament Cell Junction Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Peptidyl-threonine Autophosphorylation Regulation Of Neurotransmitter Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Structural Constituent Of Cytoskeleton Nucleotide Binding Regulation Of Norepinephrine Uptake Structural Constituent Of Postsynapse Acetylcholine Receptor Activator Activity Axonogenesis Transporter Regulator Activity Platelet Morphogenesis Regulation Of Endocannabinoid Signaling Pathway ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Positive Regulation Of Transport Regulation Of Transepithelial Transport Cell Adhesion Lamellipodium Cell-cell Junction Regulation Of Protein Localization Protein Localization To Adherens Junction Dense Body Cell Junction Regulation Of Synaptic Plasticity Calcium- And Calmodulin-dependent Protein Kinase Complex