TUBA4A and TBCE

Number of citations of the paper that reports this interaction (PubMedID 9265649)
38

Data Source:
HPRD (in vitro)

		TUBA4A	TBCE
Description		tubulin alpha 4a	tubulin folding cofactor E
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Protein Binding Alpha-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Microtubule Cytoskeleton Organization Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Mitotic Spindle Organization Axonogenesis Adult Locomotory Behavior Post-embryonic Development Muscle Atrophy Developmental Growth Peripheral Nervous System Neuron Axonogenesis
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Post-chaperonin tubulin folding pathway
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases			Kenny-Caffey syndrome Hypoparathyroidism-retardation-dysmorphism syndrome; Sanjad-Sakati syndrome
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Adiposity ( 19557161) Blood protein levels ( 30072576) First year height change in growth hormone-treated short stature ( 32652002) Household income (MTAG) ( 31844048)
Interacting Genes		53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70	4 interacting genes: AKT1 OGT TBCD TUBA4A
Entrez ID		7277	6905
HPRD ID		01851	05381
Ensembl ID		ENSG00000127824	ENSG00000284770
Uniprot IDs		P68366	A0A2R8Y6Q1 Q15813
PDB IDs			4ICU 4ICV
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Regulation Of Translational Initiation Regulation Of Translation TOR Signaling Negative Regulation Of Protein Ubiquitination Translation Negative Regulation Of Translational Initiation Phosphatidylinositol-3,4,5-trisphosphate Binding Response To Heat Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Response To Peptide Hormone TORC1 Signaling Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of RNA Biosynthetic Process Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Cytoplasmic Translation Response To Temperature Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Protein Localization To Cell Periphery Potassium Channel Activator Activity Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Regulation Of Glucose Metabolic Process Response To Hormone Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling
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