TUBA4A and GRM7

Number of citations of the paper that reports this interaction (PubMedID 11953448)
40

Data Source:
HPRD (in vivo, in vitro)

		TUBA4A	GRM7
Description		tubulin alpha 4a	glutamate metabotropic receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome	Plasma Membrane Cell Cortex Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Protein Dimerization Activity Serine Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic Axon Development Glycosylation
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	Glutamic acid
Diseases
GWAS		Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)	Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cognitive function in longevity ( 33607172) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70	14 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8
Entrez ID		7277	2917
HPRD ID		01851	04979
Ensembl ID		ENSG00000127824	ENSG00000196277
Uniprot IDs		P68366	B2R693 B7ZKK0 B9EGG9 Q14831 Q59G95
PDB IDs			3MQ4 5C5C 7EPC 7EPD
Enriched GO Terms of Interacting Partners?		Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly	Cytoskeleton Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Structural Constituent Of Cytoskeleton Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Mitotic Cell Cycle Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling GTP Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Microtubule Cytoskeleton Organization Calcineurin-mediated Signaling Presynaptic Cytosol Microtubule Cytoskeleton Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transporter Binding Spindle Microtubule Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Microtubule Calcium Channel Regulator Activity Cytoskeleton Organization Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Positive Regulation Of Sequestering Of Calcium Ion Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Synaptic Plasticity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?