TUBA4A and B4GALT1

Number of citations of the paper that reports this interaction (PMID 7744867)
23

Data Source:
HPRD (in vivo)

		TUBA4A	B4GALT1
Gene Name		tubulin, alpha 4a	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Glycocalyx Filopodium Brush Border Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Protein Homodimerization Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Notch Signaling Pathway Single Fertilization Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Proliferation Oligosaccharide Biosynthetic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Mammary Gland Development Multicellular Organism Reproduction Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Development Of Secondary Sexual Characteristics Branching Morphogenesis Of An Epithelial Tube Leukocyte Migration Regulation Of Cellular Component Movement Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Fertilization N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Interaction With The Zona Pellucida
Drugs		Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel	N-Acetyl-D-glucosamine 6-Aminohexyl-Uridine-C1,5\'-Diphosphate Di(N-Acetyl-D-Glucosamine) Uridine Diphosphate Galactose Uridine-5\'-Monophosphate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS			IgG glycosylation ( 23382691) Urate levels ( 23263486)
Protein-Protein Interactions		49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70	6 interactors: CDK11A LALBA TFRC TUBA1A TUBA4A TUBB
Entrez ID		7277	2683
HPRD ID		01851	00659
Ensembl ID		ENSG00000127824	ENSG00000086062
Uniprot IDs		A8MUB1 P68366	P15291
PDB IDs			2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process	Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Cell Cycle Process Cellular Protein Complex Assembly Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Microtubule Cytoskeleton Organization Cell Cycle Cellular Macromolecular Complex Assembly Lactose Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Disaccharide Metabolic Process Protein Complex Assembly Cytoskeleton Organization Protein Folding Iron Ion Import Organelle Organization Positive Regulation Of Bone Resorption Oligosaccharide Biosynthetic Process Cell Division Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Positive Regulation Of Tissue Remodeling Transferrin Transport Leukocyte Mediated Cytotoxicity Cellular Component Assembly Cellular Response To Cytokine Stimulus Regulation Of Bone Resorption Establishment Of Localization In Cell Regulation Of Bone Remodeling Osteoclast Differentiation Response To Cytokine Oligosaccharide Metabolic Process Cellular Response To Drug Cellular Localization Regulation Of Tissue Remodeling
Tagcloud ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Difference) ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0
Tagcloud (Intersection) ?