TUBA4A and VAV1

Number of citations of the paper that reports this interaction (PMID 8530437)
12

Data Source:
HPRD (in vivo, in vitro)

		TUBA4A	VAV1
Gene Name		tubulin, alpha 4a	vav 1 guanine nucleotide exchange factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome	Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization
Drugs		Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS			Periodontitis ( 23459936)
Protein-Protein Interactions		49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70	77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		7277	7409
HPRD ID		01851	01284
Ensembl ID		ENSG00000127824	ENSG00000141968
Uniprot IDs		A8MUB1 P68366	B2R8B5 P15498 Q96D37
PDB IDs			2CRH 2LCT 2MC1 2ROR 3BJI 3KY9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process
Tagcloud ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Difference) ?		34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Intersection) ?