VASP and FYB1

Number of citations of the paper that reports this interaction (PubMedID 10747096)
86

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VASP	FYB1
Description		vasodilator stimulated phosphoprotein	FYN binding protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Protein-containing Complex Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Signaling Receptor Binding Protein Binding Lipid Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Immune Response Integrin-mediated Signaling Pathway T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions	Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Sleep (1/2-day periodicity) ( 33075057)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	16 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC UBC VASP WAS
Entrez ID		7408	2533
HPRD ID		03415	04107
Ensembl ID		ENSG00000125753	ENSG00000082074
Uniprot IDs		A0A024R0V4 P50552	O15117
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU	1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	SH3 Domain Binding Actin Filament Organization Immune System Process Leukocyte Activation T Cell Receptor Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Profilin Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Supramolecular Fiber Organization Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Cytosol Immune Response-activating Signaling Pathway Cytoplasm Regulation Of Immune Response Phospholipase Binding Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cellular Component Organization Response To Platelet-derived Growth Factor Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Lymphocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Plasma Membrane Response To Growth Factor Regulation Of Actin Polymerization Or Depolymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Actin Filament Length Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Signal Complex Assembly Lamellipodium Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Protein-containing Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction
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