FYB1 and CBLB

Number of citations of the paper that reports this interaction (PubMedID 16503409)
0

Data Source:
HPRD (in vivo)

		FYB1	CBLB
Description		FYN binding protein 1	Cbl proto-oncogene B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Protein-containing Complex Anchoring Junction	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft Postsynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune Response Integrin-mediated Signaling Pathway T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Positive Regulation Of T Cell Anergy T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of Protein Catabolic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Sleep (1/2-day periodicity) ( 33075057)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840 28445677 31604244) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		16 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC UBC VASP WAS	53 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70
Entrez ID		2533	868
HPRD ID		04107	05136
Ensembl ID		ENSG00000082074	ENSG00000114423
Uniprot IDs		O15117	B3KSS7 B4DYP3 B7ZAG1 Q13191
PDB IDs		1RI9 2GTJ 2GTO	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI 8GCY 8QNG 8QNH 8QNI 8QTG 8QTH 8QTJ 8QTK 8VW4 8VW5 9FQH 9FQI 9FQJ
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Actin Filament Organization Immune System Process Leukocyte Activation T Cell Receptor Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Profilin Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Supramolecular Fiber Organization Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Cytosol Immune Response-activating Signaling Pathway Cytoplasm Regulation Of Immune Response Phospholipase Binding Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cellular Component Organization Response To Platelet-derived Growth Factor Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Lymphocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Plasma Membrane Response To Growth Factor Regulation Of Actin Polymerization Or Depolymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Actin Filament Length Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Signal Complex Assembly Lamellipodium Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Protein-containing Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell Motility Positive Regulation Of Cell Communication Cytoplasm Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Intracellular Signaling Cassette Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Leukocyte Migration Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Lymphocyte Activation Lamellipodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lamellipodium Organization Regulation Of Cell Activation Fc-epsilon Receptor Signaling Pathway Leukocyte Activation Immune System Process Cytosol T Cell Activation Positive Regulation Of Cell Activation
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