VASP and SHROOM3

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (proximity labelling technology, unspecified method)

		VASP	SHROOM3
Description		vasodilator stimulated phosphoprotein	shroom family member 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Actin Binding Actin Filament Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Cell Morphogenesis Actin Filament Organization Pattern Specification Process Regulation Of Cell Shape Cellular Pigment Accumulation Apical Protein Localization
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Cardiometabolic and hematological traits ( 27668658) Chronic kidney disease ( 20383146 31152163 26831199) Coronary artery disease ( 29212778) Craniofacial microsomia ( 26853712) Creatinine levels ( 20383145 31015462 29403010) Estimated glomerular filtration rate ( 31451708 31152163 31015462 29124443 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 23535967 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 24777453 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Magnesium levels ( 26058915 20700443) Microalbuminuria ( 31511532) Myocardial infarction ( 33532862) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	4 interacting genes: DYNLL1 PTEN UBC VASP
Entrez ID		7408	57619
HPRD ID		03415	07053
Ensembl ID		ENSG00000125753	ENSG00000138771
Uniprot IDs		A0A024R0V4 P50552	B3KY47 Q8TF72
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU	6FBB 6FCP
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	Negative Regulation Of Synaptic Vesicle Clustering Plasma Membrane Bounded Cell Projection Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Phosphorylation Rhythmic Synaptic Transmission Negative Regulation Of Phosphate Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Cellular Component Size Locomotor Rhythm Phosphatidylinositol-3-phosphate Phosphatase Activity Enzyme Binding Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Prepulse Inhibition Neuron-neuron Synaptic Transmission Meiotic Spindle Assembly Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Myelin Maintenance Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Parental Behavior Protein Tag Activity Profilin Binding Negative Regulation Of Nitric Oxide Biosynthetic Process Nitric-oxide Synthase Regulator Activity Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing
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