VASP and SCGB2A2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		VASP	SCGB2A2
Description		vasodilator stimulated phosphoprotein	secretoglobin family 2A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Protein Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Androgen Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	HIV-1 viral setpoint ( 26039976) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	6 interacting genes: CASP8 CDKN2C LSP1 SCGB1D2 TREM2 VASP
Entrez ID		7408	4250
HPRD ID		03415	05712
Ensembl ID		ENSG00000125753	ENSG00000110484
Uniprot IDs		A0A024R0V4 P50552	Q13296 Q6NX70
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	Positive Regulation Of Proteolysis Response To Anesthetic Negative Regulation Of Canonical NF-kappaB Signal Transduction Ripoptosome Regulation Of Interleukin-1 Production Death Effector Domain Binding Regulation Of Myeloid Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptotic Inflammatory Response Positive Regulation Of Leukocyte Differentiation CD95 Death-inducing Signaling Complex Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Myeloid Cell Differentiation Scaffold Protein Binding Lamellipodium Regulation Of Cytokine-mediated Signaling Pathway Myeloid Leukocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Macrophage Fusion Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Fat Cell Proliferation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of CD40 Signaling Pathway Positive Regulation Of CAMKK-AMPK Signaling Cascade Respiratory Burst After Phagocytosis Negative Regulation Of Autophagic Cell Death Positive Regulation Of Complement Activation Detection Of Lipoteichoic Acid Detection Of Lipopolysaccharide Excitatory Synapse Pruning Complement-mediated Synapse Pruning Positive Regulation Of Microglial Cell Migration Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Apolipoprotein A-I Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Microglial Cell Activation Involved In Immune Response Regulation Of Astrocyte Activation Very-low-density Lipoprotein Particle Binding Positive Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Synapse Pruning
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