VASP and AEBP1

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		VASP	AEBP1
Description		vasodilator stimulated phosphoprotein	AE binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Extracellular Matrix Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Carboxypeptidase Activity Metallocarboxypeptidase Activity Extracellular Matrix Structural Constituent Calmodulin Binding Collagen Binding Zinc Ion Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Proteolysis Peptide Metabolic Process Protein Processing Regulation Of Collagen Fibril Organization
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Carpal tunnel syndrome ( 30833571)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	3 interacting genes: GRB2 TCF3 VASP
Entrez ID		7408	165
HPRD ID		03415	04281
Ensembl ID		ENSG00000125753	ENSG00000106624
Uniprot IDs		A0A024R0V4 P50552	Q8IUX7
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Actin Polymerization Or Depolymerization SH3 Domain Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Actin Filament Length Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Grb2-EGFR Complex Vitamin D Response Element Binding Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Lymphocyte Activation Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Branching Involved In Labyrinthine Layer Morphogenesis Actin Cytoskeleton Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Activation Regulation Of Supramolecular Fiber Organization Neurotrophin TRKA Receptor Binding B Cell Lineage Commitment Immunoglobulin V(D)J Recombination Profilin Binding Lymphocyte Activation Insulin Receptor Substrate Binding Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Lymphocyte Activation Positive Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Leukocyte Activation Filopodium Membrane Schwann Cell Development V(D)J Recombination Cell Activation Regulation Of Cell Activation Lamellipodium Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Ephrin Receptor Binding BHLH Transcription Factor Binding Epidermal Growth Factor Receptor Binding COP9 Signalosome Insulin-like Growth Factor Receptor Signaling Pathway Somatic Recombination Of Immunoglobulin Gene Segments Endodermal Cell Differentiation
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