VASP and NR4A1

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		VASP	NR4A1
Description		vasodilator stimulated phosphoprotein	nuclear receptor subfamily 4 group A member 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Nuclear Speck Nuclear Membrane
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lipopolysaccharide Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Inflammatory Response Signal Transduction Intracellular Receptor Signaling Pathway Detection Of Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Macrophage Activation Positive Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Non-canonical Inflammasome Complex Assembly
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	86 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		7408	3164
HPRD ID		03415	00744
Ensembl ID		ENSG00000125753	ENSG00000123358
Uniprot IDs		A0A024R0V4 P50552	F5GXF0 P22736 Q6ZMM6
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1 8WUY 8Y7L
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process TOR Signaling Positive Regulation Of RNA Metabolic Process TORC1 Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Binding Ubiquitin Protein Ligase Binding Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Positive Regulation Of Biosynthetic Process Protein-containing Complex Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleoplasm Intrinsic Apoptotic Signaling Pathway Response To Nutrient Levels Identical Protein Binding MRNA Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Metabolic Process Response To Hormone Negative Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Oxygen Levels MRNA Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Primary Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?