VASP and FAT1

Number of citations: 55 (PubMedID 15148305)
Data Source: BioGRID (pull down)

		VASP	FAT1
Name		vasodilator stimulated phosphoprotein	FAT atypical cadherin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Nucleus Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Lens Development In Camera-type Eye Epithelial Cell Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Camera-type Eye Development Cell-cell Adhesion Mediated By Cadherin Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Camera-type Eye Morphogenesis Cell-cell Adhesion Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions	None
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 )	Alzheimer disease and age of onset ( 26830138 ) Carotid plaque burden ( 28282560 ) Chronotype ( 26955885 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Macular thickness ( 30535121 ) Major depressive disorder ( 29317602 ) Medication use (calcium channel blockers) ( 31015401 ) Mild obesity-related type 2 diabetes ( 34737425 ) Morning vs. evening chronotype ( 26955885 ) Obesity ( 21552555 ) PR interval ( 30046033 32439900 ) Triglyceride levels in HIV infection ( 33109212 ) Urinary albumin-to-creatinine ratio ( 31630189 )
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP
Entrez ID		7408	2195
HPRD ID		03415	02986
Ensembl ID		ENSG00000125753	ENSG00000083857
Uniprot IDs		A0A024R0V4 P50552	Q14517
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU	Not available
GO Terms Enriched among Interactors		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	G Protein-coupled Glutamate Receptor Binding Profilin Binding SH3 Domain Binding G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Anchoring Junction WW Domain Binding Dendrite Lamellipodium Postsynapse Glutamate Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Synaptic Transmission, Glutamatergic Filopodium Signaling Adaptor Activity Protein Tetramerization