VASP and XPO6

Number of citations of the paper that reports this interaction (PubMedID 14592989)
61

Data Source:
HPRD (in vitro)

		VASP	XPO6
Description		vasodilator stimulated phosphoprotein	exportin 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Protein Export From Nucleus Intracellular Protein Transport Protein Transport
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Apolipoprotein A1 levels ( 32203549) Monocyte count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX	7 interacting genes: ACTB DIAPH1 NUP62 PFN1 RNF10 SMAD3 VASP
Entrez ID		7408	23214
HPRD ID		03415	10525
Ensembl ID		ENSG00000125753	ENSG00000169180
Uniprot IDs		A0A024R0V4 P50552	Q96QU8
PDB IDs		1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization	Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Cytoskeleton Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Actin Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Lung Blood Pressure Regulation Of Supramolecular Fiber Organization Nuclear Mineralocorticoid Receptor Binding Regulation Of Actin Filament-based Process Focal Adhesion Actin Filament Positive Regulation Of Protein Polymerization Neural Tube Closure Positive Regulation Of Cellular Component Organization Tube Closure Cell Junction Organization Regulation Of Stress Fiber Assembly Ubiquitin Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Transforming Growth Factor Beta3 Production Blood Microparticle Regulation Of Actin Filament Polymerization Transporter Regulator Activity Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Tube Formation PTB Domain Binding Mitotic Spindle Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Transepithelial Transport Regulation Of Lung Blood Pressure Cytoplasm Negative Regulation Of Cell Differentiation
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