FYB and WAS

Number of citations of the paper that reports this interaction (PMID 10747096)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		FYB	WAS
Gene Name		FYN binding protein	Wiskott-Aldrich syndrome
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Actin Cytoskeleton	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Protein Complex Binding	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Biological_process Intracellular Signal Transduction T Cell Receptor Signaling Pathway	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		TCR signaling Generation of second messenger molecules Signal regulatory protein (SIRP) family interactions Adaptive Immune System	TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2
Entrez ID		2533	7454
HPRD ID		04107	02314
Ensembl ID		ENSG00000082074	ENSG00000015285
Uniprot IDs		O15117 Q05DE9	P42768
PDB IDs		1RI9 2GTJ 2GTO	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Signaling Cell Communication Actin Filament Organization Signal Transduction Cell Activation Actin Polymerization Or Depolymerization Response To Stimulus Cellular Response To Stimulus Chemotaxis Actin Cytoskeleton Organization Actin Filament-based Process Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Immune Response Platelet Activation Leukocyte Activation Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Response To Growth Factor Wound Healing Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Neuron Projection Morphogenesis Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Wounding Cell Morphogenesis Involved In Differentiation Locomotion Regulation Of Cellular Component Organization	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling
Tagcloud ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib
Tagcloud (Difference) ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib
Tagcloud (Intersection) ?