FYB and SH2D1A

Number of citations of the paper that reports this interaction (PMID 12458214)
10

Data Source:
HPRD (in vitro, in vivo)

		FYB	SH2D1A
Gene Name		FYN binding protein	SH2 domain containing 1A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Actin Cytoskeleton	Cytoplasm
	Molecular Function	Receptor Binding Protein Binding Protein Complex Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Biological_process Intracellular Signal Transduction T Cell Receptor Signaling Pathway	Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		TCR signaling Generation of second messenger molecules Signal regulatory protein (SIRP) family interactions Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	19 interactors: ARHGEF6 ARHGEF7 CD84 DOK1 EGFR ERBB3 FYB FYN GRB2 LCK LHX4 LY9 MAPK1 MAPK11 MAPK14 SLAMF1 SLAMF6 SLAMF7 TNK2
Entrez ID		2533	4068
HPRD ID		04107	02390
Ensembl ID		ENSG00000082074	ENSG00000183918
Uniprot IDs		O15117 Q05DE9	O60880
PDB IDs		1RI9 2GTJ 2GTO	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Signaling Cell Communication Actin Filament Organization Signal Transduction Cell Activation Actin Polymerization Or Depolymerization Response To Stimulus Cellular Response To Stimulus Chemotaxis Actin Cytoskeleton Organization Actin Filament-based Process Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Immune Response Platelet Activation Leukocyte Activation Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Response To Growth Factor Wound Healing Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Neuron Projection Morphogenesis Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Wounding Cell Morphogenesis Involved In Differentiation Locomotion Regulation Of Cellular Component Organization See more	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Immune Response Locomotion Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Cell Activation Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Phosphorylation Wound Healing Chemotaxis Response To Stimulus Phosphorylation Positive Regulation Of Immune Response Platelet Activation Response To Organic Substance Axon Guidance Response To Wounding Blood Coagulation Ras Protein Signal Transduction Hemostasis Positive Regulation Of Protein Phosphorylation MAPK Cascade Response To Stress Signal Transduction Cellular Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide See more
Tagcloud ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib	abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Difference) ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib	abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Intersection) ?