FYB and SKAP1

Number of citations of the paper that reports this interaction (PMID 9748251)
27

Data Source:
HPRD (two hybrid)

		FYB	SKAP1
Gene Name		FYN binding protein	src kinase associated phosphoprotein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Actin Cytoskeleton	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction
	Molecular Function	Receptor Binding Protein Binding Protein Complex Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding SH2 Domain Binding
	Biological Process	Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Biological_process Intracellular Signal Transduction T Cell Receptor Signaling Pathway	Positive Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter T Cell Receptor Signaling Pathway
Pathways		TCR signaling Generation of second messenger molecules Signal regulatory protein (SIRP) family interactions Adaptive Immune System
Drugs
Diseases
GWAS			Epilepsy (generalized) ( 22949513) Ovarian cancer ( 20852632)
Protein-Protein Interactions		14 interactors: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 SH2D1A SKAP1 SKAP2 SRC VASP WAS	12 interactors: APP BLCAP FAM102A FYB FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		2533	8631
HPRD ID		04107	05396
Ensembl ID		ENSG00000082074	ENSG00000141293
Uniprot IDs		O15117 Q05DE9	Q86WV1
PDB IDs		1RI9 2GTJ 2GTO	1U5D
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Signaling Cell Communication Actin Filament Organization Signal Transduction Cell Activation Actin Polymerization Or Depolymerization Response To Stimulus Cellular Response To Stimulus Chemotaxis Actin Cytoskeleton Organization Actin Filament-based Process Axon Guidance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Immune Response Platelet Activation Leukocyte Activation Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Response To Growth Factor Wound Healing Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Neuron Projection Morphogenesis Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Wounding Cell Morphogenesis Involved In Differentiation Locomotion Regulation Of Cellular Component Organization	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Blood Coagulation Hemostasis Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Immune System Process Leukocyte Migration Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Fc Receptor Signaling Pathway Wound Healing Chemotaxis Regulation Of Cell Adhesion Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Locomotion Response To Wounding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Innate Immune Response Neuron Projection Development Cell Migration Cell Projection Morphogenesis Regulation Of Phosphorus Metabolic Process
Tagcloud ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		agglutination alloantigens allotypic antigens antiglobulin arm coded delta disequilibria disequilibrium duffy existence fc fya granulocyte haplotype haplotypes hypothetical immunomodulatory immunophagocytosis indirect linkage lr na1 na2 phenotypes responder riia riiib	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?