FYB1 and LCP2

Number of citations of the paper that reports this interaction (PubMedID 9207119)
37

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		FYB1	LCP2
Description		FYN binding protein 1	lymphocyte cytosolic protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Protein-containing Complex Anchoring Junction	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding	Protein Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Sleep (1/2-day periodicity) ( 33075057)	Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		16 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC UBC VASP WAS	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		2533	3937
HPRD ID		04107	03362
Ensembl ID		ENSG00000082074	ENSG00000043462
Uniprot IDs		O15117	Q13094
PDB IDs		1RI9 2GTJ 2GTO	1H3H 1YWO 2EAP 2ROR 6ZCJ
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Actin Filament Organization Immune System Process Leukocyte Activation T Cell Receptor Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Profilin Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Supramolecular Fiber Organization Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Cytosol Immune Response-activating Signaling Pathway Cytoplasm Regulation Of Immune Response Phospholipase Binding Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cellular Component Organization Response To Platelet-derived Growth Factor Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Lymphocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Plasma Membrane Response To Growth Factor Regulation Of Actin Polymerization Or Depolymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Actin Filament Length Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Signal Complex Assembly Lamellipodium Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Protein-containing Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction	Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling
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