H2AC18 and RNF20

Number of citations of the paper that reports this interaction (PubMedID 21443952)
36

Data Source:
BioGRID (enzymatic study)

		H2AC18	RNF20
Description		H2A clustered histone 18	ring finger protein 20
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
	Biological Process	Heterochromatin Formation	Protein Polyubiquitination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		18 interacting genes: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBE2H USP16 USP21	41 interacting genes: AIRIM AMOTL2 ATM BAG4 CDC73 DIS3L EEF1D FBH1 FGFR4 H2AC18 H2AC20 H2AC4 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RAD51 RB1CC1 RBPMS RPA1 RPA2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17
Entrez ID		8337	56254
HPRD ID		08851	07410
Ensembl ID		ENSG00000288825	ENSG00000155827
Uniprot IDs		Q6FI13	Q5VTR2
PDB IDs		6SE6 6SEE 6SEF 6SEG 6Y5D 7JZV 9FGQ 9GMK 9GMR	5TRB 8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromatin Binding Histone Binding Nucleosome Binding Epigenetic Regulation Of Gene Expression Post-translational Protein Modification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process RING-like Zinc Finger Domain Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Ubiquitin Ligase Complex Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H2A Deubiquitinase Activity Positive Regulation Of Macromolecule Metabolic Process Proteolysis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-modified Histone Reader Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process	Structural Constituent Of Chromatin Chromosome, Telomeric Region Nucleus Nucleosome Ubiquitin Conjugating Enzyme Activity Nucleoplasm Chromosome Chromatin Organization Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Heterodimerization Activity Chromatin Remodeling DNA Repair Telomere Maintenance Protein Localization To Chromosome PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Double-strand Break Repair Chromosome Organization DNA Recombination Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Cellular Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Cycle Process DNA Metabolic Process Protein Polyubiquitination DNA Binding Positive Regulation Of MRNA 3'-end Processing HULC Complex Nuclear Division MRNA 3'-end Processing DNA Damage Response Endodermal Cell Fate Commitment Protein-DNA Complex Assembly Site Of Double-strand Break Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of DNA Metabolic Process Post-translational Protein Modification Meiotic Telomere Clustering
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