HIST2H2AA3 and NOC2L

Number of citations of the paper that reports this interaction (PMID 16322561)
17

Data Source:
BioGRID (pull down)

		HIST2H2AA3	NOC2L
Gene Name		histone cluster 2, H2aa3	nucleolar complex associated 2 homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding Nucleosome Binding Histone Binding Poly(A) RNA Binding Repressing Transcription Factor Binding
	Biological Process	Biological_process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Apoptotic Process Chromatin Assembly Nucleolus To Nucleoplasm Transport Cellular Response To UV Negative Regulation Of Histone Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF2 RNF20 TBL1X UBE2H USP16 USP21	10 interactors: APP ATN1 ATXN7 HIST2H2AA3 HIST2H2BA HIST3H3 HIST4H4 LRIF1 PPP1CA RBFOX1
Entrez ID		8337	26155
HPRD ID		08851	13166
Ensembl ID			ENSG00000188976
Uniprot IDs		Q6FI13	Q9Y3T9
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Chromatin Modification Histone Modification Organelle Organization Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Histone Deubiquitination Histone Monoubiquitination Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Protein Monoubiquitination Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Catabolic Process	Neuron Apoptotic Process Nucleobase-containing Compound Metabolic Process Neuron Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance Regulation Of Gene Expression Neuromuscular Process Controlling Balance Cellular Nitrogen Compound Metabolic Process Gene Expression Synaptic Growth At Neuromuscular Junction Nitrogen Compound Metabolic Process Neuromuscular Process Collateral Sprouting In Absence Of Injury Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling DNA Replication-dependent Nucleosome Assembly Regulation Of Glycogen Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Maintenance Of Cell Polarity DNA Methylation On Cytosine Toxin Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Chromatin Silencing At RDNA Cellular Metabolic Process
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