H2AC18 and RNF169

Number of citations of the paper that reports this interaction (PubMedID 28406400)
109

Data Source:
BioGRID (pull down)

		H2AC18	RNF169
Description		H2A clustered histone 18	ring finger protein 169
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Heterochromatin Formation	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization DNA Damage Response Protein Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		18 interacting genes: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBE2H USP16 USP21	11 interacting genes: CEP70 DYRK1A GOLGA2 H2AC18 H2AC4 H2AZ1 HOOK2 HSF2BP PIBF1 UBC UBE2E1
Entrez ID		8337	254225
HPRD ID		08851	19383
Ensembl ID		ENSG00000288825	ENSG00000166439
Uniprot IDs		Q6FI13	Q8NCN4
PDB IDs		6SE6 6SEE 6SEF 6SEG 6Y5D 7JZV 9FGQ 9GMK 9GMR	5GG4 5VEY
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromatin Binding Histone Binding Nucleosome Binding Epigenetic Regulation Of Gene Expression Post-translational Protein Modification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process RING-like Zinc Finger Domain Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Ubiquitin Ligase Complex Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H2A Deubiquitinase Activity Positive Regulation Of Macromolecule Metabolic Process Proteolysis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-modified Histone Reader Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Gene Expression Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Metabolic Process Chromatin Remodeling Centrosome Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Mitotic Spindle Assembly Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Negative Regulation Of Biosynthetic Process Cytoskeleton Chromatin Organization Protein Heterodimerization Activity Negative Regulation Of Prostaglandin Biosynthetic Process Mitotic Spindle Organization Spindle Assembly Microtubule Organizing Center Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Interleukin-4 Receptor Binding Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Glycosylation Microtubule Cytoskeleton Organization ISG15 Transferase Activity Activation Of Janus Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Heterochromatin Formation FHF Complex Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Golgi Disassembly ISG15-protein Conjugation Regulation Of Protein Glycosylation Barr Body Female Meiosis I Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Protein Localization To Perinuclear Region Of Cytoplasm
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