H2AC18 and IL33

Number of citations: 18 (PubMedID 18688256)
Data Source: BioGRID (pull down)

		H2AC18	IL33
Name		H2A clustered histone 18	interleukin 33
Structure
GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Transport Vesicle Cytoplasmic Vesicle
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding
	Biological Process	Heterochromatin Formation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Negative Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Protein Import Into Nucleus Response To Wounding Positive Regulation Of Cellular Defense Response Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Gene Expression Macrophage Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-33-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of Macrophage Activation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microglial Cell Proliferation Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of Macrophage Proliferation Antibacterial Innate Immune Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Allergic rhinitis ( 31361310 30013184 ) Allergy ( 27182965 ) Asthma ( 21804549 34103634 32296059 31959851 31619474 31361310 30929738 29785011 27182965 20860503 29273806 ) Asthma (adult onset) ( 30929738 31036433 ) Asthma (childhood onset) ( 24241537 29273806 30929738 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma (time to onset) ( 27130862 ) Asthma and hay fever ( 24388013 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Childhood asthma with severe exacerbations ( 33328473 ) Chronic rhinosinusitis ( 30643255 ) Eczema ( 31361310 ) Endometriosis ( 23472165 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (antihistamines for systemic use) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Nasal polyps ( 30643255 ) Neutrophil percentage of white cells ( 32888494 ) Periodontal microbiota ( 22699663 ) Self-reported allergy ( 23817569 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 ) Small cell lung carcinoma ( 28604730 )
Novel Interactors		1 novel interactors: VPS45	None recorded
Interacting Genes		18 interacting genes: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBE2H USP16 USP21	6 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1 MDM2
Entrez ID		8337	90865
HPRD ID		08851	12275
Ensembl ID		ENSG00000288825	ENSG00000137033
Uniprot IDs		Q6FI13	O95760
PDB IDs		6SE6 6SEE 6SEF 6SEG 6Y5D 7JZV 9FGQ 9GMK 9GMR	2KLL 4KC3
GO Terms Enriched among Interactors		Chromatin Organization Chromatin Remodeling Chromatin Binding Histone Binding Nucleosome Binding Epigenetic Regulation Of Gene Expression Post-translational Protein Modification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process RING-like Zinc Finger Domain Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Ubiquitin Ligase Complex Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H2A Deubiquitinase Activity Positive Regulation Of Macromolecule Metabolic Process Proteolysis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-modified Histone Reader Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process	AIM2 Inflammasome Complex IPAF Inflammasome Complex AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Negative Regulation Of Neuron Projection Development Response To Vitamin B1 Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Cellular Response To Actinomycin D Nucleosome Structural Constituent Of Chromatin Interleukin-33 Binding Interleukin-33 Receptor Activity Positive Regulation Of Inflammatory Response NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cytokine Precursor Processing Negative Regulation Of Cell Projection Organization Cellular Response To UV-C NLRP1 Inflammasome Complex Dihydropyrimidinase Activity Receptor Serine/threonine Kinase Binding Interleukin-1 Receptor Activity