HIST2H2AA3 and IL33

Number of citations of the paper that reports this interaction (PMID 18688256)
29

Data Source:
BioGRID (pull down)

		HIST2H2AA3	IL33
Gene Name		histone cluster 2, H2aa3	interleukin 33
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Extracellular Space Nucleus Chromosome Transport Vesicle
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Cytokine Activity Protein Binding
	Biological Process	Biological_process	Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Transcription, DNA-templated Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Type 2 Immune Response Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Immunoglobulin Secretion Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Asthma ( 21804549 20860503) Endometriosis ( 23472165) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		16 interactors: APP BAP1 BMI1 DNAJC2 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF2 RNF20 TBL1X UBE2H USP16 USP21	5 interactors: CASP1 CRMP1 HIST2H2AA3 HIST2H2BE IL1RL1
Entrez ID		8337	90865
HPRD ID		08851	12275
Ensembl ID			ENSG00000137033
Uniprot IDs		Q6FI13	O95760
PDB IDs			2KLL 4KC3
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Chromatin Modification Histone Modification Organelle Organization Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Histone Deubiquitination Histone Monoubiquitination Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Protein Monoubiquitination Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Catabolic Process	Positive Regulation Of Cytokine Secretion Interleukin-33-mediated Signaling Pathway Regulation Of Cytokine Secretion Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Protein Secretion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Regulation Of Inflammatory Response Immune Response Negative Regulation Of T-helper 1 Type Immune Response Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Activation Regulation Of Protein Secretion Interleukin-1 Beta Production Positive Regulation Of Interleukin-5 Production Innate Immune Response In Mucosa Response To Bacterium Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Regulation Of Macrophage Activation Regulation Of Interleukin-5 Production Response To ATP Antibacterial Humoral Response Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Transport Immune System Process Positive Regulation Of Interleukin-1 Production Mucosal Immune Response Regulation Of Secretion Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Negative Regulation Of Adaptive Immune Response Membrane Hyperpolarization Pyrimidine Nucleobase Metabolic Process Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Chemokine Production Positive Regulation Of Transport
Tagcloud ?			10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?			10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?