HDAC6 and NEDD8

Number of citations: 74 (PubMedID 34642328)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		HDAC6	NEDD8
Name		histone deacetylase 6	NEDD8 ubiquitin like modifier
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Centrosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Caveola Cilium Microtubule Cytoskeleton Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Protein-containing Complex Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Deacetylase Activity Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Protein Lysine Deacetylase Activity Peroxidase Inhibitor Activity ATPase Inhibitor Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Metal Ion Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Response To Amphetamine Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Response To Stress Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Neuron Projection Development Macroautophagy Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Positive Regulation Of Protein Oligomerization Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Immobilization Stress Cellular Response To Topologically Incorrect Protein Aggrephagy Erythrocyte Enucleation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Collateral Sprouting Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Response To Corticosterone Mitochondrion Localization Response To Misfolded Protein Positive Regulation Of Synaptic Transmission, Glutamatergic Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Cilium Disassembly Type 2 Mitophagy Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Misfolded Protein Cellular Response To Parathyroid Hormone Stimulus Response To Dexamethasone Tubulin Deacetylation Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation Membraneless Organelle Assembly Positive Regulation Of Cellular Response To Oxidative Stress Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Aggrephagy	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs		Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	None
GWAS		No GWAS studies recorded	Mean corpuscular volume ( 29403010 ) Systolic blood pressure (cigarette smoking interaction) ( 26752167 )
Interacting Genes		83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CRBN CSNK2A2 CYLD DSCR9 DYNLL2 EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H2AX H4C16 HDAC11 HES1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MOB1A MSH2 NACAD NASP NEDD8 NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF168 RNF31 RUNX2 SEPTIN7 SIRT2 SYK TEKT4 TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 ZBTB16 ZNF205	71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		10013	4738
HPRD ID		02228	04412
Ensembl ID		ENSG00000094631	ENSG00000129559
Uniprot IDs		B4DZH6 Q9BRX7 Q9UBN7	Q15843
PDB IDs		3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF 7ZYU 8G43 8G44 8G45	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
GO Terms Enriched among Interactors		Nucleus Protein Modification Process Cytosol Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Protein-containing Complex Protein Modification By Small Protein Conjugation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Stress Microtubule Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Deacetylation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Nucleoplasm Protein Tag Activity Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly Glial Cell Differentiation Positive Regulation Of Developmental Process DNA Damage Response Cell Differentiation Cellular Response To Stress Developmental Process Regulation Of DNA-templated Transcription Regulation Of Signaling Regulation Of Cell Communication	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm