HDAC6 and KPNA1

Number of citations: 30 (PubMedID 22778253)
Data Source: BioGRID (pull down)

		HDAC6	KPNA1
Name		histone deacetylase 6	karyopherin subunit alpha 1
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Centrosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Caveola Cilium Microtubule Cytoskeleton Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Protein-containing Complex Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection Axon Cytoplasm	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Deacetylase Activity Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Protein Lysine Deacetylase Activity Peroxidase Inhibitor Activity ATPase Inhibitor Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Metal Ion Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding Histone Deacetylase Activity, Hydrolytic Mechanism	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Polyubiquitination Response To Amphetamine Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Response To Stress Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Neuron Projection Development Macroautophagy Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Positive Regulation Of Protein Oligomerization Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Immobilization Stress Cellular Response To Topologically Incorrect Protein Aggrephagy Erythrocyte Enucleation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Collateral Sprouting Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Response To Corticosterone Mitochondrion Localization Response To Misfolded Protein Positive Regulation Of Synaptic Transmission, Glutamatergic Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Cilium Disassembly Type 2 Mitophagy Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Misfolded Protein Cellular Response To Parathyroid Hormone Stimulus Response To Dexamethasone Tubulin Deacetylation Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation Membraneless Organelle Assembly Positive Regulation Of Cellular Response To Oxidative Stress Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Aggrephagy	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production
Drugs		Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac	None
GWAS		No GWAS studies recorded	Calcium levels ( 20705733 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 28334899 ) Mean corpuscular hemoglobin ( 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 )
Interacting Genes		83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CRBN CSNK2A2 CYLD DSCR9 DYNLL2 EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H2AX H4C16 HDAC11 HES1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MOB1A MSH2 NACAD NASP NEDD8 NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF168 RNF31 RUNX2 SEPTIN7 SIRT2 SYK TEKT4 TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 ZBTB16 ZNF205	49 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5
Entrez ID		10013	3836
HPRD ID		02228	02819
Ensembl ID		ENSG00000094631	ENSG00000114030
Uniprot IDs		B4DZH6 Q9BRX7 Q9UBN7	P52294
PDB IDs		3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF 7ZYU 8G43 8G44 8G45	2JDQ 3TJ3 4B18 6WX9
GO Terms Enriched among Interactors		Nucleus Protein Modification Process Cytosol Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Protein-containing Complex Protein Modification By Small Protein Conjugation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Stress Microtubule Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Deacetylation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Nucleoplasm Protein Tag Activity Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly Glial Cell Differentiation Positive Regulation Of Developmental Process DNA Damage Response Cell Differentiation Cellular Response To Stress Developmental Process Regulation Of DNA-templated Transcription Regulation Of Signaling Regulation Of Cell Communication	Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination