HDAC6 and POLDIP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HDAC6	POLDIP2
Gene Name		histone deacetylase 6	polymerase (DNA-directed), delta interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Mitochondrial Nucleoid
	Molecular Function	Core Promoter Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	DNA Binding
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Protein Deacetylation Misfolded Or Incompletely Synthesized Protein Catabolic Process Intracellular Protein Transport Organelle Organization Negative Regulation Of Microtubule Depolymerization Response To Toxic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Receptor Activity Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Macroautophagy Histone Deacetylation Lysosome Localization Cellular Response To Heat Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Complex Disassembly Negative Regulation Of Protein Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death	Mitochondrion Morphogenesis
Pathways		HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ADRB2 ADRBK1 ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CORD1 CSNK2A2 CTNNB1 CTTN CYLD EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB G3BP1 HDAC11 HES1 HIST4H4 HSP90AA1 JDP2 KPNA1 LCOR LPXN MAPK3 NACAD NASP NR0B2 NR3C1 PKN1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PTOV1 PXN RELB RUNX2 SIRT2 SYK TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 ZBTB16 ZNF205	14 interactors: ALAS1 APP ASCC2 CPE HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN REV1 SELENBP1 TAB1
Entrez ID		10013	26073
HPRD ID		02228	17874
Ensembl ID		ENSG00000094631	ENSG00000004142
Uniprot IDs		Q9UBN7	Q9Y2S7
PDB IDs		3C5K 3GV4 3PHD
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process RNA Biosynthetic Process Protein Complex Assembly Positive Regulation Of Protein Modification Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Death Defense Response Regulation Of Nitrogen Compound Metabolic Process Death Positive Regulation Of Transferase Activity Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response Mitotic Cell Cycle	Translesion Synthesis Postreplication Repair DNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process DNA Repair DNA Replication Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Nucleobase-containing Compound Metabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair DNA Recombination Cellular Metabolic Process Cellular Response To Stimulus Mismatch Repair Base-excision Repair Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Deoxyribonuclease Activity Hsp90 Deacetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Catalytic Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport Nucleotide-excision Repair Regulation Of Protein Processing Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger	atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Difference) ?		amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger	atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Intersection) ?