HDAC6 and POLR1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HDAC6	POLR1B
Gene Name		histone deacetylase 6	polymerase (RNA) I polypeptide B, 128kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm	Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm
	Molecular Function	Core Promoter Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase I Activity DNA Binding Protein Binding Ribonucleoside Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Protein Deacetylation Misfolded Or Incompletely Synthesized Protein Catabolic Process Intracellular Protein Transport Organelle Organization Negative Regulation Of Microtubule Depolymerization Response To Toxic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Receptor Activity Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Macroautophagy Histone Deacetylation Lysosome Localization Cellular Response To Heat Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Complex Disassembly Negative Regulation Of Protein Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Gene Expression Nucleologenesis Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ADRB2 ADRBK1 ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CORD1 CSNK2A2 CTNNB1 CTTN CYLD EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB G3BP1 HDAC11 HES1 HIST4H4 HSP90AA1 JDP2 KPNA1 LCOR LPXN MAPK3 NACAD NASP NR0B2 NR3C1 PKN1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PTOV1 PXN RELB RUNX2 SIRT2 SYK TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 ZBTB16 ZNF205	14 interactors: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207
Entrez ID		10013	84172
HPRD ID		02228	06852
Ensembl ID		ENSG00000094631	ENSG00000125630
Uniprot IDs		Q9UBN7	Q9H9Y6
PDB IDs		3C5K 3GV4 3PHD
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process RNA Biosynthetic Process Protein Complex Assembly Positive Regulation Of Protein Modification Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Death Defense Response Regulation Of Nitrogen Compound Metabolic Process Death Positive Regulation Of Transferase Activity Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response Mitotic Cell Cycle	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Metabolic Process Mammary Gland Epithelium Development Mammary Gland Epithelial Cell Proliferation Transcription Initiation From RNA Polymerase I Promoter Mammary Gland Development Transcription From RNA Polymerase I Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Histone H3-K4 Acetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Hsp90 Deacetylation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Positive Regulation Of Hemoglobin Biosynthetic Process Polyubiquitinated Misfolded Protein Transport Epithelial Cell Proliferation Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Prostate Epithelial Cord Elongation Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Cellular Response To Topologically Incorrect Protein Regulation Of Type I Interferon Production
Tagcloud ?		amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Difference) ?		amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Intersection) ?