GGA3 and PACS1

Number of citations of the paper that reports this interaction (PMID 16977309)
20

Data Source:
HPRD (in vivo, in vitro)

		GGA3	PACS1
Gene Name		golgi-associated, gamma adaptin ear containing, ARF binding protein 3	phosphofurin acidic cluster sorting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex	Cytosol COPI-coated Vesicle
	Molecular Function	Protein Binding ADP-ribosylation Factor Binding	Protein Binding Ion Channel Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process	Protein Targeting To Golgi Viral Process Regulation Of Defense Response To Virus By Virus Protein Targeting To Plasma Membrane
Pathways			Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		24 interactors: AFTPH AP1S2 ARF1 ARF3 BACE1 CDKN2A CLINT1 CLTC GGA1 GGA2 IGF2R M6PR PACS1 RAB5A RABEP1 RNF11 RPS27A STAB1 SYNRG TBC1D3 TSG101 UBC VPS11 VPS18	10 interactors: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		23163	55690
HPRD ID		10443	06320
Ensembl ID		ENSG00000125447	ENSG00000175115
Uniprot IDs		A8K6I6 A8K6M0 Q9NZ52	Q6VY07
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Transport Cellular Localization Intracellular Protein Transport Membrane Organization Viral Protein Processing Endocytosis Cellular Protein Localization Viral Process Virion Assembly Post-Golgi Vesicle-mediated Transport Endosomal Transport Regulation Of Defense Response To Virus By Virus Intracellular Transport Of Virus Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Receptor-mediated Endocytosis Viral Life Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Membrane Budding Regulation Of Defense Response To Virus Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Ubiquitin-protein Transferase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Notch Receptor Processing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle-mediated Transport G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Receptor Internalization Negative Regulation Of Cell Cycle Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Ubiquitination	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Catabolic Process Liver Development Cell Death Death Cell Surface Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Phosphate-containing Compound Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Cellular Response To Potassium Ion Starvation Negative Regulation Of Cellular Protein Catabolic Process Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Regulation Of Endothelial Cell Proliferation Response To Oxidative Stress Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Cellular Protein Modification Process Response To Inorganic Substance Protein Kinase D Signaling Leading Edge Cell Differentiation Nerve Growth Factor Production Metanephric Smooth Muscle Tissue Development Detection Of Nodal Flow Renal Artery Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Gland Development Regulation Of Receptor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Protein Catabolic Process Transport Response To Hydrogen Peroxide Negative Regulation Of Transforming Growth Factor Beta1 Production
Tagcloud ?		acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs	acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored
Tagcloud (Difference) ?		acylation adaptin anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs	acidic adaptor amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored
Tagcloud (Intersection) ?		adaptors