GGA3 and TBC1D3

Number of citations of the paper that reports this interaction (PubMedID 18199687)
60

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GGA3	TBC1D3
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	TBC1 domain family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane	Endosome Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity	GTPase Activator Activity
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process	Regulation Of Cilium Assembly
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	TBC/RABGAPs
Drugs
Diseases
GWAS			Ovarian cancer ( 23535730)
Interacting Genes		45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	3 interacting genes: CLIC3 GGA3 ZRANB1
Entrez ID		23163	729873
HPRD ID		10443	19677
Ensembl ID		ENSG00000125447	ENSG00000274611
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	Q6IPX1 Q8IZP1
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity	Protein-disulfide Reductase (glutathione) Activity Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
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