GGA3 and ARAP3

Number of citations of the paper that reports this interaction (PubMedID 17314030)
0

Data Source:
BioGRID (two hybrid)

		GGA3	ARAP3
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS			Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	11 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 SNCA TNKS2
Entrez ID		23163	64411
HPRD ID		10443	09441
Ensembl ID		ENSG00000125447	ENSG00000120318
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	2KG5 2LNW 5JCP 5JD0 7A9B 7YIR 7YIS
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity	Cell Death ERK1 And ERK2 Cascade Apoptotic Process SH3 Domain Binding Vesicle-mediated Transport Actin Filament Organization Establishment Of Organelle Localization Cell Projection Programmed Cell Death Regulation Of Immune System Process Supramolecular Fiber Organization MAPK Cascade Response To Desipramine Negative Regulation Of Norepinephrine Uptake Protein Complex Oligomerization Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Destabilization Protein-containing Complex Cell-cell Junction DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Plasma Membrane Bounded Cell Projection Assembly Regulation Of Amide Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Neuron Projection DATP Catabolic Process DGTP Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Assembly Actin Binding Protein Tetramerization Cellular Component Assembly Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Secretion By Cell Anchoring Junction DGTP Metabolic Process Regulated Exocytosis Regulation Of Immune Response Endocytosis Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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