GGA3 and ETS1

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GGA3	ETS1
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	ETS proto-oncogene 1, transcription factor
Image
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation PML Body Organization Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of MiRNA Transcription Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	Oncogene Induced Senescence
Drugs
Diseases
GWAS			Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 20190752 22057235 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 31959993 30054594 29785010 29617998) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 30423114 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 19838193 20169177 23273568 28714469 27399966 26502338 26663301) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 30718926 30297969 30054458) Ulcerative colitis ( 28067908) White blood cell count ( 27863252 32888494)
Interacting Genes		45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	54 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREB1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 GGA1 GGA2 GGA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		23163	2113
HPRD ID		10443	01260
Ensembl ID		ENSG00000125447	ENSG00000134954
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	A8K725 B4DW78 P14921
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Transcription Regulator Complex Negative Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Identical Protein Binding Nucleus Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-templated Transcription Cellular Response To Growth Factor Stimulus Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Transcription Coactivator Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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