GGA3 and ADRA2A

Number of citations of the paper that reports this interaction (PubMedID 26811329)
56

Data Source:
BioGRID (pull down)

		GGA3	ADRA2A
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	adrenoceptor alpha 2A
Image
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Neuronal Cell Body Receptor Complex Axon Terminus Postsynaptic Membrane Presynaptic Active Zone Membrane Dopaminergic Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process	Positive Regulation Of Cytokine Production DNA Replication Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Vasodilation Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Response To Alcohol Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Dihydroergotamine Amitriptyline Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Prochlorperazine Dipivefrin Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Paroxetine Trimipramine Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Promethazine Carvedilol Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Periciazine Zuclopenthixol Celiprolol Dronedarone Lofexidine Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Tetryzoline Lurasidone Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Moxonidine Pirlindole Pipamperone Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Xylazine Indigotindisulfonic acid Rilmenidine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS			Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fish- and plant-related diet ( 32066663) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)
Interacting Genes		45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ
Entrez ID		23163	150
HPRD ID		10443	00078
Ensembl ID		ENSG00000125447	ENSG00000150594
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	P08913
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	1HLL 1HO9 1HOD 1HOF 6K42 6KUX 6KUY 7EJ0 7EJ8 7EJA 7EJK 7W6P 7W7E 9CBL 9CBM
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity	Heterotrimeric G-protein Complex Alpha-2A Adrenergic Receptor Binding Response To Prostaglandin E Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Plasma Membrane D2 Dopamine Receptor Binding G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Acetylcholine Receptor Signaling Pathway Response To Hormone Regulation Of The Force Of Heart Contraction By Chemical Signal Postsynaptic Signal Transduction Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Heart Contraction Membrane Regulation Of Protein Localization To Cell Cortex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Circulation Response To Alcohol Regulation Of System Process Regulation Of Biological Quality Regulation Of Relaxation Of Muscle Signal Transduction Cellular Response To Catecholamine Stimulus Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Activity Positive Regulation Of Superoxide Anion Generation Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Regulation Of MAPK Cascade Cellular Response To Prostaglandin Stimulus Transmembrane Transporter Binding Regulation Of The Force Of Heart Contraction Negative Regulation Of Secretion By Cell
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