GGA3 and GTPBP4

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GGA3	GTPBP4
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	GTP binding protein 4
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Preribosome Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Osteoblast Differentiation Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Protein Stabilization
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS			Height ( 28552196)
Interacting Genes		45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	8 interacting genes: COPB1 GGA1 GGA2 GGA3 PRKN SRPK2 USP7 YWHAG
Entrez ID		23163	23560
HPRD ID		10443	09976
Ensembl ID		ENSG00000125447	ENSG00000107937
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	D2CFK9 Q9BZE4
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8	6LSS 6LU8 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity	Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Regulation Of Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Regulation Of Protein Stability Regulation Of Protein Catabolic Process Vesicle-mediated Transport To The Plasma Membrane Protein K6-linked Ubiquitination Intracellular Protein Localization Intracellular Protein Transport Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Vesicle-mediated Transport Intracellular Transport Presynapse Protein Stabilization Protein Catabolic Process Protein Localization To Cell Periphery Protein Localization To Organelle Establishment Of Protein Localization Golgi Apparatus Protein Destabilization Protein Localization To Lysosome Endosome Membrane Small GTPase Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Prostaglandin F Receptor Activity TORC1 Signaling Protein Localization To Membrane Protein-containing Complex Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Interleukin-2 Receptor Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination
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