TNFRSF4 and BTG2

Data Source: HiPPIP (Novel)

		TNFRSF4	BTG2
Name		TNF receptor superfamily member 4	BTG anti-proliferation factor 2
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Damage Response Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Differentiation Neuron Projection Development Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Neural Precursor Cell Proliferation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		TNFs bind their physiological receptors	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
GWAS		Inflammatory bowel disease ( 23128233 )	Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	16 interacting genes: CCNB1 CDK1 CNOT7 CNOT8 HOXB9 HOXC8 MAPK14 MAPK3 PICK1 PIN1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1
Entrez ID		7293	7832
HPRD ID		02636	03357
Ensembl ID		ENSG00000186827	ENSG00000159388
Uniprot IDs		A0A8V8TQH5 P43489	P78543
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1	3DJU 3E9V
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production	Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Cyclin B1-CDK1 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Transcription By RNA Polymerase II Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Heart Growth Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Organ Growth Regulation Of MRNA Metabolic Process CCR4-NOT Core Complex G2/M Transition Of Mitotic Cell Cycle Mitogen-activated Protein Kinase P38 Binding SMAD Protein Complex Nucleus Cytosol Cell Cycle G2/M Phase Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Heteromeric SMAD Protein Complex Regulation Of MRNA Stability Response To Mechanical Stimulus Regulation Of Heart Growth Ventricular Cardiac Muscle Cell Development Nucleic Acid Metabolic Process Regulation Of RNA Stability Mitotic Nuclear Membrane Disassembly Poly(A)-specific Ribonuclease Activity G1/S Transition Of Mitotic Cell Cycle