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TNFRSF4
Gene Name
tumor necrosis factor receptor superfamily, member 4
Image
Gene Ontology Annotations
Cellular Component
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Molecular Function
Tumor Necrosis Factor-activated Receptor Activity
Biological Process
Inflammatory Response
Immune Response
Cellular Defense Response
Positive Regulation Of B Cell Proliferation
Tumor Necrosis Factor-mediated Signaling Pathway
T Cell Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cytokine Secretion
Positive Regulation Of Immunoglobulin Secretion
Pathways
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-protein Interactions
8 interactors:
SIVA1
TNFRSF9
TNFSF4
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
Entrez ID
7293
HPRD ID
02636
Ensembl ID
ENSG00000186827
Uniprot IDs
P43489
PDB IDs
1D0A
2HEV
2HEY
Enriched GO Terms of Interacting Partners
?
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Positive Regulation Of Protein Homodimerization Activity
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Immunoglobulin Secretion
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homotrimerization
Positive Regulation Of T Cell Cytokine Production
Regulation Of Cytokine Production
Regulation Of Protein Homodimerization Activity
Activation Of NF-kappaB-inducing Kinase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of T Cell Cytokine Production
Negative Regulation Of Cytokine Production
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Protein Trimerization
Positive Regulation Of Interleukin-2 Production
Negative Regulation Of Cytokine Secretion
Positive Regulation Of Cytokine Production Involved In Immune Response
Signal Transduction
Negative Regulation Of NF-kappaB Transcription Factor Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Interleukin-12 Production
Regulation Of Cellular Localization
Positive Regulation Of Protein Binding
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Protein Secretion
Regulation Of Cytokine Production Involved In Immune Response
Signaling
Cell Communication
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
Cellular Response To Nitrogen Dioxide
Response To Nitrogen Dioxide
T-helper 2 Cell Activation
Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
CD4-positive, Alpha-beta T Cell Costimulation
Memory T Cell Activation
Cellular Response To Tumor Necrosis Factor
Tagcloud
?
assembles
bcl10
carma1
cbm
cd134
cd252
cd28
contributor
detergent
dim
directs
expand
malt1
microdomains
ox40
ox40l
persist
pkctheta
primed
rafts
raising
rip1
signalosome
superfamily
tcr
translocates
works